Henn C - Search Results

1

Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization.

Klein T, Henn C, de Jong JC, Zimmer C, Kirsch B, Maurer CK, Pistorius D, Müller R, Steinbach A, Hartmann RW. Klein T, et al. Among authors: henn c. ACS Chem Biol. 2012 Sep 21;7(9):1496-501. doi: 10.1021/cb300208g. Epub 2012 Jul 5. ACS Chem Biol. 2012. PMID: 22765028

2

Discovery of antagonists of PqsR, a key player in 2-alkyl-4-quinolone-dependent quorum sensing in Pseudomonas aeruginosa.

Lu C, Kirsch B, Zimmer C, de Jong JC, Henn C, Maurer CK, Müsken M, Häussler S, Steinbach A, Hartmann RW. Lu C, et al. Among authors: henn c. Chem Biol. 2012 Mar 23;19(3):381-90. doi: 10.1016/j.chembiol.2012.01.015. Chem Biol. 2012. PMID: 22444593

3

Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence.

Zender M, Klein T, Henn C, Kirsch B, Maurer CK, Kail D, Ritter C, Dolezal O, Steinbach A, Hartmann RW. Zender M, et al. Among authors: henn c. J Med Chem. 2013 Sep 12;56(17):6761-74. doi: 10.1021/jm400830r. Epub 2013 Aug 21. J Med Chem. 2013. PMID: 23919758

4

Catalytic enzyme activity on a biosensor chip: combination of surface plasmon resonance and mass spectrometry.

Henn C, Boettcher S, Steinbach A, Hartmann RW. Henn C, et al. Anal Biochem. 2012 Sep 1;428(1):28-30. doi: 10.1016/j.ab.2012.05.024. Epub 2012 Jun 4. Anal Biochem. 2012. PMID: 22677626

5

Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies.

Steinbach A, Maurer CK, Weidel E, Henn C, Brengel C, Hartmann RW, Negri M. Steinbach A, et al. Among authors: henn c. BMC Biophys. 2013 Aug 1;6(1):10. doi: 10.1186/2046-1682-6-10. BMC Biophys. 2013. PMID: 23916145 Free PMC article.

6

Mechanistic details for anthraniloyl transfer in PqsD: the initial step in HHQ biosynthesis.

Hutter MC, Brengel C, Negri M, Henn C, Zimmer C, Hartmann RW, Empting M, Steinbach A. Hutter MC, et al. Among authors: henn c. J Mol Model. 2014 Jun;20(6):2255. doi: 10.1007/s00894-014-2255-z. Epub 2014 May 15. J Mol Model. 2014. PMID: 24842325

7

Bicyclic substituted hydroxyphenylmethanone type inhibitors of 17 β-hydroxysteroid dehydrogenase Type 1 (17 β-HSD1): the role of the bicyclic moiety.

Oster A, Klein T, Henn C, Werth R, Marchais-Oberwinkler S, Frotscher M, Hartmann RW. Oster A, et al. Among authors: henn c. ChemMedChem. 2011 Mar 7;6(3):476-87. doi: 10.1002/cmdc.201000457. Epub 2011 Feb 17. ChemMedChem. 2011. PMID: 21337522

8

Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation.

Klein T, Henn C, Negri M, Frotscher M. Klein T, et al. Among authors: henn c. PLoS One. 2011;6(8):e22990. doi: 10.1371/journal.pone.0022990. Epub 2011 Aug 9. PLoS One. 2011. PMID: 21857977 Free PMC article.

9

Lead optimization of 17β-HSD1 inhibitors of the (hydroxyphenyl)naphthol sulfonamide type for the treatment of endometriosis.

Henn C, Einspanier A, Marchais-Oberwinkler S, Frotscher M, Hartmann RW. Henn C, et al. J Med Chem. 2012 Apr 12;55(7):3307-18. doi: 10.1021/jm201735j. Epub 2012 Mar 16. J Med Chem. 2012. PMID: 22380653

10

17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.

Marchais-Oberwinkler S, Henn C, Möller G, Klein T, Negri M, Oster A, Spadaro A, Werth R, Wetzel M, Xu K, Frotscher M, Hartmann RW, Adamski J. Marchais-Oberwinkler S, et al. Among authors: henn c. J Steroid Biochem Mol Biol. 2011 May;125(1-2):66-82. doi: 10.1016/j.jsbmb.2010.12.013. Epub 2010 Dec 28. J Steroid Biochem Mol Biol. 2011. PMID: 21193039 Review.

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