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Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overload.
Ulasova E, Gladden JD, Chen Y, Zheng J, Pat B, Bradley W, Powell P, Zmijewski JW, Zelickson BR, Ballinger SW, Darley-Usmar V, Dell'italia LJ. Ulasova E, et al. Among authors: chen y. J Mol Cell Cardiol. 2011 Jan;50(1):147-56. doi: 10.1016/j.yjmcc.2010.10.034. Epub 2010 Nov 6. J Mol Cell Cardiol. 2011. PMID: 21059354 Free PMC article.
Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog.
Zheng J, Chen Y, Pat B, Dell'italia LA, Tillson M, Dillon AR, Powell PC, Shi K, Shah N, Denney T, Husain A, Dell'Italia LJ. Zheng J, et al. Among authors: chen y. Circulation. 2009 Apr 21;119(15):2086-95. doi: 10.1161/CIRCULATIONAHA.108.826230. Epub 2009 Apr 6. Circulation. 2009. PMID: 19349319 Free PMC article.
Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation.
Pat B, Chen Y, Killingsworth C, Gladden JD, Shi K, Zheng J, Powell PC, Walcott G, Ahmed MI, Gupta H, Desai R, Wei CC, Hase N, Kobayashi T, Sabri A, Granzier H, Denney T, Tillson M, Dillon AR, Husain A, Dell'italia LJ. Pat B, et al. Among authors: chen y. Circulation. 2010 Oct 12;122(15):1488-95. doi: 10.1161/CIRCULATIONAHA.109.921619. Epub 2010 Sep 27. Circulation. 2010. PMID: 20876440 Free PMC article.
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