Friedrich S - Search Results

1

The effects on metabolic clearance when administering a potent CYP3A autoinducer with the prototypic CYP3A inhibitor, ketoconazole.

Ayan-Oshodi MA, Willis BA, Annes WF, Lowe SL, Friedrich S, de la Peña A, Zhang W, Brown T, Wise SD, Hall SD. Ayan-Oshodi MA, et al. Among authors: friedrich s. Drug Metab Dispos. 2012 Oct;40(10):1945-52. doi: 10.1124/dmd.112.046060. Epub 2012 Jul 12. Drug Metab Dispos. 2012. PMID: 22789530 Clinical Trial.

2

Safety, tolerability, and effects on plasma and cerebrospinal fluid amyloid-beta after inhibition of gamma-secretase.

Siemers ER, Dean RA, Friedrich S, Ferguson-Sells L, Gonzales C, Farlow MR, May PC. Siemers ER, et al. Among authors: friedrich s. Clin Neuropharmacol. 2007 Nov-Dec;30(6):317-25. doi: 10.1097/WNF.0b013e31805b7660. Clin Neuropharmacol. 2007. PMID: 18090456 Clinical Trial.

3

Semagacestat pharmacokinetics are not significantly affected by formulation, food, or time of dosing in healthy participants.

Willis BA, Zhang W, Ayan-Oshodi M, Lowe SL, Annes WF, Sirois PJ, Friedrich S, de la Peña A. Willis BA, et al. Among authors: friedrich s. J Clin Pharmacol. 2012 Jun;52(6):904-13. doi: 10.1177/0091270011407195. Epub 2011 Jul 1. J Clin Pharmacol. 2012. PMID: 21724950 Clinical Trial.

4

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor.

May PC, Dean RA, Lowe SL, Martenyi F, Sheehan SM, Boggs LN, Monk SA, Mathes BM, Mergott DJ, Watson BM, Stout SL, Timm DE, Smith Labell E, Gonzales CR, Nakano M, Jhee SS, Yen M, Ereshefsky L, Lindstrom TD, Calligaro DO, Cocke PJ, Greg Hall D, Friedrich S, Citron M, Audia JE. May PC, et al. Among authors: friedrich s. J Neurosci. 2011 Nov 16;31(46):16507-16. doi: 10.1523/JNEUROSCI.3647-11.2011. J Neurosci. 2011. PMID: 22090477 Free PMC article. Clinical Trial.

5

Comparison of pharmacokinetics, pharmacodynamics, safety, and tolerability of the amyloid β monoclonal antibody solanezumab in Japanese and white patients with mild to moderate alzheimer disease.

Uenaka K, Nakano M, Willis BA, Friedrich S, Ferguson-Sells L, Dean RA, Ieiri I, Siemers ER. Uenaka K, et al. Among authors: friedrich s. Clin Neuropharmacol. 2012 Jan-Feb;35(1):25-9. doi: 10.1097/WNF.0b013e31823a13d3. Clin Neuropharmacol. 2012. PMID: 22134132 Clinical Trial.

6

Evacetrapib at a supratherapeutic steady state concentration does not prolong QT in a thorough QT/QTc study in healthy participants.

Suico JG, Friedrich S, Krueger KA, Zhang W. Suico JG, et al. Among authors: friedrich s. J Cardiovasc Pharmacol Ther. 2014 May;19(3):283-9. doi: 10.1177/1074248413510784. Epub 2013 Nov 22. J Cardiovasc Pharmacol Ther. 2014. PMID: 24271137 Clinical Trial.

7

Assessment of the persistence of anacetrapib and evacetrapib concentrations using two pharmacokinetic modeling approaches.

Small DS, Ke AB, Hall SD, Mantlo N, Rotelli M, Friedrich S. Small DS, et al. Among authors: friedrich s. J Clin Pharmacol. 2015 Jul;55(7):757-67. doi: 10.1002/jcph.472. Epub 2015 Feb 20. J Clin Pharmacol. 2015. PMID: 25651523

8

A Multidose Study to Examine the Effect of Food on Evacetrapib Exposure at Steady State.

Small DS, Zhang W, Royalty J, Cannady EA, Downs D, Friedrich S, Suico JG. Small DS, et al. Among authors: friedrich s. J Cardiovasc Pharmacol Ther. 2015 Sep;20(5):483-9. doi: 10.1177/1074248415575153. Epub 2015 Mar 3. J Cardiovasc Pharmacol Ther. 2015. PMID: 25736283 Free PMC article. Clinical Trial.

9

CYP-mediated drug-drug interactions with evacetrapib, an investigational CETP inhibitor: in vitro prediction and clinical outcome.

Cannady EA, Suico JG, Wang MD, Friedrich S, Rehmel JR, Nicholls SJ, Krueger KA. Cannady EA, et al. Among authors: friedrich s. Br J Clin Pharmacol. 2015 Dec;80(6):1388-98. doi: 10.1111/bcp.12730. Epub 2015 Oct 27. Br J Clin Pharmacol. 2015. PMID: 26264702 Free PMC article. Clinical Trial.

10

Evacetrapib: in vitro and clinical disposition, metabolism, excretion, and assessment of drug interaction potential with strong CYP3A and CYP2C8 inhibitors.

Cannady EA, Wang MD, Friedrich S, Rehmel JL, Yi P, Small DS, Zhang W, Suico JG. Cannady EA, et al. Among authors: friedrich s. Pharmacol Res Perspect. 2015 Oct;3(5):e00179. doi: 10.1002/prp2.179. Epub 2015 Oct 12. Pharmacol Res Perspect. 2015. PMID: 26516590 Free PMC article.

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