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Page 1
Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases.
Vandenbroucke RE, Dejonckheere E, Van Lint P, Demeestere D, Van Wonterghem E, Vanlaere I, Puimège L, Van Hauwermeiren F, De Rycke R, Mc Guire C, Campestre C, López-Otin C, Matthys P, Leclercq G, Libert C. Vandenbroucke RE, et al. Among authors: demeestere d. J Neurosci. 2012 Jul 18;32(29):9805-16. doi: 10.1523/JNEUROSCI.0967-12.2012. J Neurosci. 2012. PMID: 22815495 Free PMC article.
Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles.
Balusu S, Van Wonterghem E, De Rycke R, Raemdonck K, Stremersch S, Gevaert K, Brkic M, Demeestere D, Vanhooren V, Hendrix A, Libert C, Vandenbroucke RE. Balusu S, et al. Among authors: demeestere d. EMBO Mol Med. 2016 Oct 4;8(10):1162-1183. doi: 10.15252/emmm.201606271. Print 2016 Oct. EMBO Mol Med. 2016. PMID: 27596437 Free PMC article.
Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.
Demeestere D, Dejonckheere E, Steeland S, Hulpiau P, Haustraete J, Devoogdt N, Wichert R, Becker-Pauly C, Van Wonterghem E, Dewaele S, Van Imschoot G, Aerts J, Arckens L, Saeys Y, Libert C, Vandenbroucke RE. Demeestere D, et al. Mol Ther. 2016 May;24(5):890-902. doi: 10.1038/mt.2016.2. Epub 2016 Jan 18. Mol Ther. 2016. PMID: 26775809 Free PMC article.
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.
Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, Daems C, Staszewski O, Vande Walle L, Jordao MJC, Sze M, Vikkula HK, Demeestere D, Van Imschoot G, Scott CL, Hoste E, Gonçalves A, Guilliams M, Lippens S, Libert C, Vandenbroucke RE, Kim KW, Jung S, Callaerts-Vegh Z, Callaerts P, de Wit J, Lamkanfi M, Prinz M, van Loo G. Voet S, et al. Among authors: demeestere d. Nat Commun. 2018 May 23;9(1):2036. doi: 10.1038/s41467-018-04376-5. Nat Commun. 2018. PMID: 29789522 Free PMC article.
Selective inhibition of anti-MAG IgM autoantibody binding to myelin by an antigen-specific glycopolymer.
Aliu B, Demeestere D, Seydoux E, Boucraut J, Delmont E, Brodovitch A, Oberholzer T, Attarian S, Théaudin M, Tsouni P, Kuntzer T, Derfuss T, Steck AJ, Ernst B, Herrendorff R, Hänggi P. Aliu B, et al. Among authors: demeestere d. J Neurochem. 2020 Sep;154(5):486-501. doi: 10.1111/jnc.15021. Epub 2020 Jun 23. J Neurochem. 2020. PMID: 32270492 Free PMC article.
Selective in vivo removal of pathogenic anti-MAG autoantibodies, an antigen-specific treatment option for anti-MAG neuropathy.
Herrendorff R, Hänggi P, Pfister H, Yang F, Demeestere D, Hunziker F, Frey S, Schaeren-Wiemers N, Steck AJ, Ernst B. Herrendorff R, et al. Among authors: demeestere d. Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3689-E3698. doi: 10.1073/pnas.1619386114. Epub 2017 Apr 17. Proc Natl Acad Sci U S A. 2017. PMID: 28416698 Free PMC article.