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899 results

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Page 1
Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury.
Dhaliwal K, Scholefield E, Ferenbach D, Gibbons M, Duffin R, Dorward DA, Morris AC, Humphries D, MacKinnon A, Wilkinson TS, Wallace WA, van Rooijen N, Mack M, Rossi AG, Davidson DJ, Hirani N, Hughes J, Haslett C, Simpson AJ. Dhaliwal K, et al. Among authors: mackinnon a. Am J Respir Crit Care Med. 2012 Sep 15;186(6):514-24. doi: 10.1164/rccm.201112-2132OC. Epub 2012 Jul 19. Am J Respir Crit Care Med. 2012. PMID: 22822022 Free PMC article.
Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis.
Gibbons MA, MacKinnon AC, Ramachandran P, Dhaliwal K, Duffin R, Phythian-Adams AT, van Rooijen N, Haslett C, Howie SE, Simpson AJ, Hirani N, Gauldie J, Iredale JP, Sethi T, Forbes SJ. Gibbons MA, et al. Among authors: mackinnon ac. Am J Respir Crit Care Med. 2011 Sep 1;184(5):569-81. doi: 10.1164/rccm.201010-1719OC. Am J Respir Crit Care Med. 2011. PMID: 21680953
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3.
Mackinnon AC, Gibbons MA, Farnworth SL, Leffler H, Nilsson UJ, Delaine T, Simpson AJ, Forbes SJ, Hirani N, Gauldie J, Sethi T. Mackinnon AC, et al. Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46. doi: 10.1164/rccm.201106-0965OC. Epub 2011 Nov 17. Am J Respir Crit Care Med. 2012. PMID: 22095546 Free PMC article.
Cerebral Concussion Primes the Lungs for Subsequent Neutrophil-Mediated Injury.
Humphries DC, O'Neill S, Scholefield E, Dorward DA, Mackinnon AC, Rossi AG, Haslett C, Andrews PJD, Rhodes J, Dhaliwal K. Humphries DC, et al. Among authors: mackinnon ac. Crit Care Med. 2018 Sep;46(9):e937-e944. doi: 10.1097/CCM.0000000000003270. Crit Care Med. 2018. PMID: 29957711 Free PMC article.
Intrapulmonary Autoantibodies to HSP72 Are Associated with Improved Outcomes in IPF.
Mills R, Mathur A, Nicol LM, Walker JJ, Przybylski AA, Mackinnon AC, Howie SEM, Wallace WAH, Dransfield I, Hirani N. Mills R, et al. Among authors: mackinnon ac. J Immunol Res. 2019 Apr 11;2019:1845128. doi: 10.1155/2019/1845128. eCollection 2019. J Immunol Res. 2019. PMID: 31098385 Free PMC article.
An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE).
Gaughan EE, Quinn TM, Mills A, Bruce AM, Antonelli J, MacKinnon AC, Aslanis V, Li F, O'Connor R, Boz C, Mills R, Emanuel P, Burgess M, Rinaldi G, Valanciute A, Mills B, Scholefield E, Hardisty G, Findlay EG, Parker RA, Norrie J, Dear JW, Akram AR, Koch O, Templeton K, Dockrell DH, Walsh TS, Partridge S, Humphries D, Wang-Jairaj J, Slack RJ, Schambye H, Phung D, Gravelle L, Lindmark B, Shankar-Hari M, Hirani N, Sethi T, Dhaliwal K. Gaughan EE, et al. Among authors: mackinnon ac. Am J Respir Crit Care Med. 2023 Jan 15;207(2):138-149. doi: 10.1164/rccm.202203-0477OC. Am J Respir Crit Care Med. 2023. PMID: 35972987 Free PMC article. Clinical Trial.
Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis.
Hirani N, MacKinnon AC, Nicol L, Ford P, Schambye H, Pedersen A, Nilsson UJ, Leffler H, Sethi T, Tantawi S, Gravelle L, Slack RJ, Mills R, Karmakar U, Humphries D, Zetterberg F, Keeling L, Paul L, Molyneaux PL, Li F, Funston W, Forrest IA, Simpson AJ, Gibbons MA, Maher TM. Hirani N, et al. Among authors: mackinnon ac. Eur Respir J. 2021 May 27;57(5):2002559. doi: 10.1183/13993003.02559-2020. Print 2021 May. Eur Respir J. 2021. PMID: 33214209 Free PMC article. Clinical Trial.
Selective Myeloid Depletion of Galectin-3 Offers Protection Against Acute and Chronic Lung Injury.
Humphries DC, Mills R, Dobie R, Henderson NC, Sethi T, Mackinnon AC. Humphries DC, et al. Front Pharmacol. 2021 Aug 30;12:715986. doi: 10.3389/fphar.2021.715986. eCollection 2021. Front Pharmacol. 2021. PMID: 34526900 Free PMC article.
Previous work has shown that global deletion of galectin-3 reduces collagen deposition in a bleomycin-induced pulmonary fibrosis model (MacKinnon et al., Am. J. Respir. Crit. ...Results: Myeloid depletion of Gal-3 led to a significant reduction in Gal-3 expre …
Previous work has shown that global deletion of galectin-3 reduces collagen deposition in a bleomycin-induced pulmonary fibrosis mode …
899 results