Hougland JL - Search Results

1

Synthesis of frame-shifted farnesyl diphosphate analogs.

Placzek AT, Hougland JL, Gibbs RA. Placzek AT, et al. Among authors: hougland jl. Org Lett. 2012 Aug 17;14(16):4038-41. doi: 10.1021/ol300683r. Epub 2012 Aug 2. Org Lett. 2012. PMID: 22857735 Free PMC article.

2

Context-dependent substrate recognition by protein farnesyltransferase.

Hougland JL, Lamphear CL, Scott SA, Gibbs RA, Fierke CA. Hougland JL, et al. Biochemistry. 2009 Mar 3;48(8):1691-701. doi: 10.1021/bi801710g. Biochemistry. 2009. PMID: 19199818 Free PMC article.

3

Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates.

Krzysiak AJ, Aditya AV, Hougland JL, Fierke CA, Gibbs RA. Krzysiak AJ, et al. Among authors: hougland jl. Bioorg Med Chem Lett. 2010 Jan 15;20(2):767-70. doi: 10.1016/j.bmcl.2009.11.011. Epub 2009 Nov 12. Bioorg Med Chem Lett. 2010. PMID: 20005705 Free PMC article.

4

Targeted reengineering of protein geranylgeranyltransferase type I selectivity functionally implicates active-site residues in protein-substrate recognition.

Gangopadhyay SA, Losito EL, Hougland JL. Gangopadhyay SA, et al. Among authors: hougland jl. Biochemistry. 2014 Jan 21;53(2):434-46. doi: 10.1021/bi4011732. Epub 2014 Jan 6. Biochemistry. 2014. PMID: 24344934

5

Structure-activity analysis of human ghrelin O-acyltransferase reveals chemical determinants of ghrelin selectivity and acyl group recognition.

Darling JE, Zhao F, Loftus RJ, Patton LM, Gibbs RA, Hougland JL. Darling JE, et al. Among authors: hougland jl. Biochemistry. 2015 Feb 3;54(4):1100-10. doi: 10.1021/bi5010359. Epub 2015 Jan 21. Biochemistry. 2015. PMID: 25562443

6

A new class of ghrelin O-acyltransferase inhibitors incorporating triazole-linked lipid mimetic groups.

Zhao F, Darling JE, Gibbs RA, Hougland JL. Zhao F, et al. Among authors: hougland jl. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2800-3. doi: 10.1016/j.bmcl.2015.05.009. Epub 2015 May 15. Bioorg Med Chem Lett. 2015. PMID: 26009163

7

Synthesis, Enzymatic Peptide Incorporation, and Applications of Diazirine-Containing Isoprenoid Diphosphate Analogues.

Justyna K, Das R, Lorimer EL, Hu J, Pedersen JS, Sprague-Getsy AM, Schey GL, Sieburg MA, Koehn OJ, Wang YC, Chen YX, Hougland JL, Williams CL, Distefano MD. Justyna K, et al. Among authors: hougland jl. Org Lett. 2023 Sep 15;25(36):6767-6772. doi: 10.1021/acs.orglett.3c02736. Epub 2023 Sep 5. Org Lett. 2023. PMID: 37669435 Free PMC article.

8

MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase.

Schey GL, Buttery PH, Hildebrandt ER, Novak SX, Schmidt WK, Hougland JL, Distefano MD. Schey GL, et al. Among authors: hougland jl. Int J Mol Sci. 2021 Nov 7;22(21):12042. doi: 10.3390/ijms222112042. Int J Mol Sci. 2021. PMID: 34769472 Free PMC article.

9

An Alkyne-Containing Isoprenoid Analogue Based on a Farnesyl Diphosphate Scaffold Is a Biologically Functional Universal Probe for Proteomic Analysis.

Auger SA, Pedersen JS, Maity S, Sprague-Getsy AM, Lorimer EL, Koehn OJ, Krauklis SA, Berns B, Murphy KM, Hussain J, Thao P, Bernhagen K, Justyna K, Sundaresan AP, McKim DB, Williams CL, Hougland JL, Li L, Distefano MD. Auger SA, et al. Among authors: hougland jl. Biochemistry. 2025 Jan 7;64(1):138-155. doi: 10.1021/acs.biochem.4c00558. Epub 2024 Dec 9. Biochemistry. 2025. PMID: 39652878

10

Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways.

Hougland JL, Gangopadhyay SA, Fierke CA. Hougland JL, et al. J Biol Chem. 2012 Nov 2;287(45):38090-100. doi: 10.1074/jbc.M112.404954. Epub 2012 Sep 19. J Biol Chem. 2012. PMID: 22992747 Free PMC article.

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