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CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy.
Waters JD, Sanchez C, Sahin A, Futalan D, Gonda DD, Scheer JK, Akers J, Palanichamy K, Waterman P, Chakravarti A, Weissleder R, Morse B, Marsh N, Furfine E, Chen CC, Carvajal I, Carter BS. Waters JD, et al. Among authors: futalan d. J Neurooncol. 2012 Oct;110(1):37-48. doi: 10.1007/s11060-012-0948-7. Epub 2012 Aug 9. J Neurooncol. 2012. PMID: 22875706 Free PMC article.
Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition.
Shen Y, Li J, Nitta M, Futalan D, Steed T, Treiber JM, Taich Z, Stevens D, Wykosky J, Chen HZ, Carter BS, Becher OJ, Kennedy R, Esashi F, Sarkaria JN, Furnari FB, Cavenee WK, Desai A, Chen CC. Shen Y, et al. Among authors: futalan d. Oncotarget. 2015 May 20;6(14):11751-67. doi: 10.18632/oncotarget.3996. Oncotarget. 2015. PMID: 26059434 Free PMC article.
Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma.
Li J, Zhu S, Kozono D, Ng K, Futalan D, Shen Y, Akers JC, Steed T, Kushwaha D, Schlabach M, Carter BS, Kwon CH, Furnari F, Cavenee W, Elledge S, Chen CC. Li J, et al. Among authors: futalan d. Oncotarget. 2014 Feb 28;5(4):882-93. doi: 10.18632/oncotarget.1801. Oncotarget. 2014. PMID: 24658464 Free PMC article.
TLR4-dependent activation of dendritic cells by an HMGB1-derived peptide adjuvant.
Saenz R, Futalan D, Leutenez L, Eekhout F, Fecteau JF, Sundelius S, Sundqvist S, Larsson M, Hayashi T, Minev B, Carson D, Esener S, Messmer B, Messmer D. Saenz R, et al. Among authors: futalan d. J Transl Med. 2014 Aug 14;12:211. doi: 10.1186/1479-5876-12-211. J Transl Med. 2014. PMID: 25123824 Free PMC article.