Helal MA - Search Results

1

Combined receptor-based and ligand-based approach to delineate the mode of binding of guaianolide-endoperoxides to PfATP6.

Helal MA, Avery MA. Helal MA, et al. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5410-4. doi: 10.1016/j.bmcl.2012.07.053. Epub 2012 Jul 20. Bioorg Med Chem Lett. 2012. PMID: 22877631

2

Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents.

Sun L, Shah F, Helal MA, Wu Y, Pedduri Y, Chittiboyina AG, Gut J, Rosenthal PJ, Avery MA. Sun L, et al. Among authors: helal ma. J Med Chem. 2010 Nov 11;53(21):7864-8. doi: 10.1021/jm1006462. J Med Chem. 2010. PMID: 20945914

3

New insights into the binding mode of melanin concentrating hormone receptor-1 antagonists: homology modeling and explicit membrane molecular dynamics simulation study.

Helal MA, Chittiboyina AG, Avery MA. Helal MA, et al. J Chem Inf Model. 2011 Mar 28;51(3):635-46. doi: 10.1021/ci100355c. Epub 2011 Mar 3. J Chem Inf Model. 2011. PMID: 21370821 Free PMC article.

4

Design, synthesis, and enzyme kinetics of novel benzimidazole and quinoxaline derivatives as methionine synthase inhibitors.

Elshihawy H, Helal MA, Said M, Hammad MA. Elshihawy H, et al. Among authors: helal ma. Bioorg Med Chem. 2014 Jan 1;22(1):550-8. doi: 10.1016/j.bmc.2013.10.052. Epub 2013 Nov 8. Bioorg Med Chem. 2014. PMID: 24268539

5

Homology modeling and explicit membrane molecular dynamics simulation to delineate the mode of binding of thiazolidinediones into FFAR1 and the mechanism of receptor activation.

Helal MA, Darwish KM, Hammad MA. Helal MA, et al. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5330-6. doi: 10.1016/j.bmcl.2014.07.043. Epub 2014 Aug 7. Bioorg Med Chem Lett. 2014. PMID: 25441945

6

Novel pyrazoles and pyrazolo[1,2-a]pyridazines as selective COX-2 inhibitors; Ultrasound-assisted synthesis, biological evaluation, and DFT calculations.

Ghareb N, Elshihawy HA, Abdel-Daim MM, Helal MA. Ghareb N, et al. Among authors: helal ma. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2377-2383. doi: 10.1016/j.bmcl.2017.04.020. Epub 2017 Apr 8. Bioorg Med Chem Lett. 2017. PMID: 28427813

7

Synthesis, biological evaluation, and molecular docking investigation of benzhydrol- and indole-based dual PPAR-γ/FFAR1 agonists.

Darwish KM, Salama I, Mostafa S, Gomaa MS, Khafagy ES, Helal MA. Darwish KM, et al. Among authors: helal ma. Bioorg Med Chem Lett. 2018 May 15;28(9):1595-1602. doi: 10.1016/j.bmcl.2018.03.051. Epub 2018 Mar 21. Bioorg Med Chem Lett. 2018. PMID: 29615345

8

Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1.

Kishk SM, McLean KJ, Sood S, Helal MA, Gomaa MS, Salama I, Mostafa SM, de Carvalho LPS, Munro AW, Simons C. Kishk SM, et al. Among authors: helal ma. Bioorg Med Chem. 2019 Apr 15;27(8):1546-1561. doi: 10.1016/j.bmc.2019.02.051. Epub 2019 Feb 27. Bioorg Med Chem. 2019. PMID: 30837169 Free PMC article.

9

Identification of a new small molecule chemotype of Melanin Concentrating Hormone Receptor-1 antagonists using pharmacophore-based virtual screening.

Helal MA, Chittiboyina AG, Avery MA. Helal MA, et al. Bioorg Med Chem Lett. 2019 Dec 15;29(24):126741. doi: 10.1016/j.bmcl.2019.126741. Epub 2019 Oct 16. Bioorg Med Chem Lett. 2019. PMID: 31678007

10

Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro.

Galal KA, Truong A, Kwarcinski F, de Silva C, Avalani K, Havener TM, Chirgwin ME, Merten E, Ong HW, Willis C, Abdelwaly A, Helal MA, Derbyshire ER, Zutshi R, Drewry DH. Galal KA, et al. Among authors: helal ma. J Med Chem. 2022 Oct 13;65(19):13172-13197. doi: 10.1021/acs.jmedchem.2c00996. Epub 2022 Sep 27. J Med Chem. 2022. PMID: 36166733 Free PMC article.

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