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Page 1
The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives.
Agelis G, Resvani A, Durdagi S, Spyridaki K, Tůmová T, Slaninová J, Giannopoulos P, Vlahakos D, Liapakis G, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: resvani a. Eur J Med Chem. 2012 Sep;55:358-74. doi: 10.1016/j.ejmech.2012.07.040. Epub 2012 Jul 31. Eur J Med Chem. 2012. PMID: 22889560
An efficient synthesis of a rationally designed 1,5 disubstituted imidazole AT(1) angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies.
Agelis G, Roumelioti P, Resvani A, Durdagi S, Androutsou ME, Kelaidonis K, Vlahakos D, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: resvani a. J Comput Aided Mol Des. 2010 Sep;24(9):749-58. doi: 10.1007/s10822-010-9371-3. Epub 2010 Jul 10. J Comput Aided Mol Des. 2010. PMID: 20623162
Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers.
Agelis G, Resvani A, Koukoulitsa C, Tůmová T, Slaninová J, Kalavrizioti D, Spyridaki K, Afantitis A, Melagraki G, Siafaka A, Gkini E, Megariotis G, Grdadolnik SG, Papadopoulos MG, Vlahakos D, Maragoudakis M, Liapakis G, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: resvani a. Eur J Med Chem. 2013 Apr;62:352-70. doi: 10.1016/j.ejmech.2012.12.044. Epub 2013 Jan 2. Eur J Med Chem. 2013. PMID: 23376252 Free article.
Facile and efficient syntheses of a series of N-benzyl and N-biphenylmethyl substituted imidazole derivatives based on (E)-urocanic acid, as angiotensin II AT1 receptor blockers.
Agelis G, Kelaidonis K, Resvani A, Kalavrizioti D, Androutsou ME, Plotas P, Vlahakos D, Koukoulitsa C, Tselios T, Mavromoustakos T, Matsoukas J. Agelis G, et al. Among authors: resvani a. Molecules. 2013 Jun 27;18(7):7510-32. doi: 10.3390/molecules18077510. Molecules. 2013. PMID: 23807577 Free PMC article.
Interactions of the potent synthetic AT1 antagonist analog BV6 with membrane bilayers and mesoporous silicate matrices.
Agelis G, Resvani A, Ntountaniotis D, Chatzigeorgiou P, Koukoulitsa C, Androutsou ME, Plotas P, Matsoukas J, Mavromoustakos T, Cendak T, Godec TU, Mali G. Agelis G, et al. Among authors: resvani a. Biochim Biophys Acta. 2013 Aug;1828(8):1846-55. doi: 10.1016/j.bbamem.2013.03.009. Epub 2013 Mar 16. Biochim Biophys Acta. 2013. PMID: 23506680 Free article.
An efficient synthetic method and theoretical calculations of olmesartan methyl ether: study of biological function of AT1 antagonism.
Ntountaniotis D, Agelis G, Resvani A, Halabalaki M, Liapakis G, Spyridaki K, Grdadolnik SG, Merzel F, Kostidis S, Potamitis C, Tselios T, Matsoukas J, Skaltsounis LA, Mavromoustakos T. Ntountaniotis D, et al. Among authors: resvani a. Comb Chem High Throughput Screen. 2014;17(8):652-62. doi: 10.2174/138620731708140922171503. Comb Chem High Throughput Screen. 2014. PMID: 24875271