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Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.
Diógenes MJ, Dias RB, Rombo DM, Vicente Miranda H, Maiolino F, Guerreiro P, Näsström T, Franquelim HG, Oliveira LM, Castanho MA, Lannfelt L, Bergström J, Ingelsson M, Quintas A, Sebastião AM, Lopes LV, Outeiro TF. Diógenes MJ, et al. Among authors: outeiro tf. J Neurosci. 2012 Aug 22;32(34):11750-62. doi: 10.1523/JNEUROSCI.0234-12.2012. J Neurosci. 2012. PMID: 22915117 Free PMC article.
Dopamine-induced conformational changes in alpha-synuclein.
Outeiro TF, Klucken J, Bercury K, Tetzlaff J, Putcha P, Oliveira LM, Quintas A, McLean PJ, Hyman BT. Outeiro TF, et al. PLoS One. 2009 Sep 4;4(9):e6906. doi: 10.1371/journal.pone.0006906. PLoS One. 2009. PMID: 19730729 Free PMC article.
Antibodies against alpha-synuclein reduce oligomerization in living cells.
Näsström T, Gonçalves S, Sahlin C, Nordström E, Screpanti Sundquist V, Lannfelt L, Bergström J, Outeiro TF, Ingelsson M. Näsström T, et al. Among authors: outeiro tf. PLoS One. 2011;6(10):e27230. doi: 10.1371/journal.pone.0027230. Epub 2011 Oct 31. PLoS One. 2011. PMID: 22073131 Free PMC article.
Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice.
Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, Kärkkäinen E, Stavén S, Vicente Miranda H, Outeiro TF, Diógenes MJ, Laroche S, Davis S, Sebastião AM, Castrén E, Tanila H. Kemppainen S, et al. Among authors: outeiro tf. Neurobiol Aging. 2012 Jun;33(6):1122.e23-39. doi: 10.1016/j.neurobiolaging.2011.11.006. Epub 2011 Dec 30. Neurobiol Aging. 2012. PMID: 22209410
Alpha-synuclein: from secretion to dysfunction and death.
Marques O, Outeiro TF. Marques O, et al. Among authors: outeiro tf. Cell Death Dis. 2012 Jul 19;3(7):e350. doi: 10.1038/cddis.2012.94. Cell Death Dis. 2012. PMID: 22825468 Free PMC article. Review.
354 results