Chambers PA - Search Results

1

Mutation detection by clonal sequencing of PCR amplicons and grouped read typing is applicable to clinical diagnostics.

Chambers PA, Stead LF, Morgan JE, Carr IM, Sutton KM, Watson CM, Crowe V, Dickinson H, Roberts P, Mulatero C, Seymour M, Markham AF, Waring PM, Quirke P, Taylor GR. Chambers PA, et al. Hum Mutat. 2013 Jan;34(1):248-54. doi: 10.1002/humu.22207. Epub 2012 Oct 11. Hum Mutat. 2013. PMID: 22915446

2

KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial.

Richman SD, Seymour MT, Chambers P, Elliott F, Daly CL, Meade AM, Taylor G, Barrett JH, Quirke P. Richman SD, et al. J Clin Oncol. 2009 Dec 10;27(35):5931-7. doi: 10.1200/JCO.2009.22.4295. Epub 2009 Nov 2. J Clin Oncol. 2009. PMID: 19884549 Clinical Trial.

3

Intra-tumoral heterogeneity of KRAS and BRAF mutation status in patients with advanced colorectal cancer (aCRC) and cost-effectiveness of multiple sample testing.

Richman SD, Chambers P, Seymour MT, Daly C, Grant S, Hemmings G, Quirke P. Richman SD, et al. Anal Cell Pathol (Amst). 2011;34(1-2):61-6. doi: 10.3233/ACP-2011-0005. Anal Cell Pathol (Amst). 2011. PMID: 21483104 Free PMC article.

4

Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer.

Hutchins G, Southward K, Handley K, Magill L, Beaumont C, Stahlschmidt J, Richman S, Chambers P, Seymour M, Kerr D, Gray R, Quirke P. Hutchins G, et al. J Clin Oncol. 2011 Apr 1;29(10):1261-70. doi: 10.1200/JCO.2010.30.1366. Epub 2011 Mar 7. J Clin Oncol. 2011. PMID: 21383284 Clinical Trial.

5

HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials.

Richman SD, Southward K, Chambers P, Cross D, Barrett J, Hemmings G, Taylor M, Wood H, Hutchins G, Foster JM, Oumie A, Spink KG, Brown SR, Jones M, Kerr D, Handley K, Gray R, Seymour M, Quirke P. Richman SD, et al. J Pathol. 2016 Mar;238(4):562-70. doi: 10.1002/path.4679. Epub 2016 Jan 29. J Pathol. 2016. PMID: 26690310 Free PMC article.

6

Integrated genomic and transcriptional analysis of the in vitro evolution of telomerase-immortalized urothelial cells (TERT-NHUC).

Chapman EJ, Williams SV, Platt FM, Hurst CD, Chambers P, Roberts P, Knowles MA. Chapman EJ, et al. Genes Chromosomes Cancer. 2009 Aug;48(8):694-710. doi: 10.1002/gcc.20672. Genes Chromosomes Cancer. 2009. PMID: 19405089

7

Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial.

Seymour MT, Brown SR, Middleton G, Maughan T, Richman S, Gwyther S, Lowe C, Seligmann JF, Wadsley J, Maisey N, Chau I, Hill M, Dawson L, Falk S, O'Callaghan A, Benstead K, Chambers P, Oliver A, Marshall H, Napp V, Quirke P. Seymour MT, et al. Lancet Oncol. 2013 Jul;14(8):749-59. doi: 10.1016/S1470-2045(13)70163-3. Epub 2013 May 29. Lancet Oncol. 2013. PMID: 23725851 Free PMC article. Clinical Trial.

8

Down-Regulation of miR-92 in Breast Epithelial Cells and in Normal but Not Tumour Fibroblasts Contributes to Breast Carcinogenesis.

Smith L, Baxter EW, Chambers PA, Green CA, Hanby AM, Hughes TA, Nash CE, Millican-Slater RA, Stead LF, Verghese ET, Speirs V. Smith L, et al. Among authors: chambers pa. PLoS One. 2015 Oct 5;10(10):e0139698. doi: 10.1371/journal.pone.0139698. eCollection 2015. PLoS One. 2015. PMID: 26437339 Free PMC article.

9

In vitro functional effects of XPC gene rare variants from bladder cancer patients.

Qiao B, Ansari AH, Scott GB, Sak SC, Chambers PA, Elliott F, Teo MT, Bentley J, Churchman M, Hall J, Taylor CF, Bishop TD, Knowles MA, Kiltie AE. Qiao B, et al. Among authors: chambers pa. Carcinogenesis. 2011 Apr;32(4):516-21. doi: 10.1093/carcin/bgr005. Epub 2011 Jan 27. Carcinogenesis. 2011. PMID: 21273643 Free PMC article.

10

Genetic and Epigenetic Intra-tumour Heterogeneity in Colorectal Cancer.

Jones HG, Jenkins G, Williams N, Griffiths P, Chambers P, Beynon J, Harris D. Jones HG, et al. World J Surg. 2017 May;41(5):1375-1383. doi: 10.1007/s00268-016-3860-z. World J Surg. 2017. PMID: 28097409 Free PMC article.

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