Lim J - Search Results

1

An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats.

Iyer A, Lim J, Poudyal H, Reid RC, Suen JY, Webster J, Prins JB, Whitehead JP, Fairlie DP, Brown L. Iyer A, et al. Among authors: lim j. Diabetes. 2012 Sep;61(9):2320-9. doi: 10.2337/db11-1179. Diabetes. 2012. PMID: 22923652 Free PMC article.

2

Structure-activity relationships for substrate-based inhibitors of human complement factor B.

Ruiz-Gómez G, Lim J, Halili MA, Le GT, Madala PK, Abbenante G, Fairlie DP. Ruiz-Gómez G, et al. Among authors: lim j. J Med Chem. 2009 Oct 8;52(19):6042-52. doi: 10.1021/jm900781m. J Med Chem. 2009. PMID: 19743866

3

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats.

Iyer A, Fenning A, Lim J, Le GT, Reid RC, Halili MA, Fairlie DP, Brown L. Iyer A, et al. Among authors: lim j. Br J Pharmacol. 2010 Apr;159(7):1408-17. doi: 10.1111/j.1476-5381.2010.00637.x. Epub 2010 Feb 24. Br J Pharmacol. 2010. PMID: 20180942 Free PMC article.

4

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling.

Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP. Lim J, et al. FASEB J. 2013 Feb;27(2):822-31. doi: 10.1096/fj.12-220582. Epub 2012 Nov 1. FASEB J. 2013. PMID: 23118029

5

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism.

Lim J, Iyer A, Liu L, Suen JY, Lohman RJ, Seow V, Yau MK, Brown L, Fairlie DP. Lim J, et al. FASEB J. 2013 Dec;27(12):4757-67. doi: 10.1096/fj.13-232702. Epub 2013 Aug 20. FASEB J. 2013. PMID: 23964081

6

Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.

Seow V, Lim J, Iyer A, Suen JY, Ariffin JK, Hohenhaus DM, Sweet MJ, Fairlie DP. Seow V, et al. Among authors: lim j. J Immunol. 2013 Oct 15;191(8):4308-16. doi: 10.4049/jimmunol.1301355. Epub 2013 Sep 16. J Immunol. 2013. PMID: 24043889

7

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.

Reid RC, Yau MK, Singh R, Hamidon JK, Reed AN, Chu P, Suen JY, Stoermer MJ, Blakeney JS, Lim J, Faber JM, Fairlie DP. Reid RC, et al. Among authors: lim j. Nat Commun. 2013;4:2802. doi: 10.1038/ncomms3802. Nat Commun. 2013. PMID: 24257095 Free article.

8

Pathway-selective antagonism of proteinase activated receptor 2.

Suen JY, Cotterell A, Lohman RJ, Lim J, Han A, Yau MK, Liu L, Cooper MA, Vesey DA, Fairlie DP. Suen JY, et al. Among authors: lim j. Br J Pharmacol. 2014 Sep;171(17):4112-24. doi: 10.1111/bph.12757. Epub 2014 Jul 2. Br J Pharmacol. 2014. PMID: 24821440 Free PMC article.

9

Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides.

Reid RC, Yau MK, Singh R, Lim J, Fairlie DP. Reid RC, et al. Among authors: lim j. J Am Chem Soc. 2014 Aug 27;136(34):11914-7. doi: 10.1021/ja506518t. Epub 2014 Aug 13. J Am Chem Soc. 2014. PMID: 25102224

10

Potent heterocyclic ligands for human complement c3a receptor.

Reid RC, Yau MK, Singh R, Hamidon JK, Lim J, Stoermer MJ, Fairlie DP. Reid RC, et al. Among authors: lim j. J Med Chem. 2014 Oct 23;57(20):8459-70. doi: 10.1021/jm500956p. Epub 2014 Oct 8. J Med Chem. 2014. PMID: 25259874

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