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Page 1
Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans.
De Ceuninck F, Kargar C, Ilic C, Caliez A, Rolin JO, Umbdenstock T, Vinson C, Combettes M, de Fanti B, Harley E, Sadlo M, Lefèvre AL, Broux O, Wierzbicki M, Fourquez JM, Perron-Sierra F, Kotschy A, Ktorza A. De Ceuninck F, et al. Among authors: lefevre al. Br J Pharmacol. 2013 Jan;168(2):339-53. doi: 10.1111/j.1476-5381.2012.02184.x. Br J Pharmacol. 2013. PMID: 22925001 Free PMC article.
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.
Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefèvre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M. Cruciani-Guglielmacci C, et al. Among authors: lefevre al. Mol Metab. 2017 Jan 26;6(4):340-351. doi: 10.1016/j.molmet.2017.01.009. eCollection 2017 Apr. Mol Metab. 2017. PMID: 28377873 Free PMC article.
Adiponectin is required to mediate rimonabant-induced improvement of insulin sensitivity but not body weight loss in diet-induced obese mice.
Migrenne S, Lacombe A, Lefèvre AL, Pruniaux MP, Guillot E, Galzin AM, Magnan C. Migrenne S, et al. Among authors: lefevre al. Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R929-35. doi: 10.1152/ajpregu.90824.2008. Epub 2009 Feb 11. Am J Physiol Regul Integr Comp Physiol. 2009. PMID: 19211723 Free article.
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.
Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ. Benoit SC, et al. Among authors: lefevre al. J Clin Invest. 2009 Sep;119(9):2577-89. doi: 10.1172/JCI36714. Epub 2009 Aug 10. J Clin Invest. 2009. PMID: 19726875 Free PMC article.