Krämer OH - Search Results

1

Breakdown of the FLT3-ITD/STAT5 axis and synergistic apoptosis induction by the histone deacetylase inhibitor panobinostat and FLT3-specific inhibitors.

Pietschmann K, Bolck HA, Buchwald M, Spielberg S, Polzer H, Spiekermann K, Bug G, Heinzel T, Böhmer FD, Krämer OH. Pietschmann K, et al. Among authors: kramer oh. Mol Cancer Ther. 2012 Nov;11(11):2373-83. doi: 10.1158/1535-7163.MCT-12-0129. Epub 2012 Aug 31. Mol Cancer Ther. 2012. PMID: 22942377

2

Histone deacetylase as a therapeutic target.

Krämer OH, Göttlicher M, Heinzel T. Krämer OH, et al. Trends Endocrinol Metab. 2001 Sep;12(7):294-300. doi: 10.1016/s1043-2760(01)00438-6. Trends Endocrinol Metab. 2001. PMID: 11504668 Review.

3

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.

Göttlicher M, Minucci S, Zhu P, Krämer OH, Schimpf A, Giavara S, Sleeman JP, Lo Coco F, Nervi C, Pelicci PG, Heinzel T. Göttlicher M, et al. Among authors: kramer oh. EMBO J. 2001 Dec 17;20(24):6969-78. doi: 10.1093/emboj/20.24.6969. EMBO J. 2001. PMID: 11742974 Free PMC article.

4

The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2.

Krämer OH, Zhu P, Ostendorff HP, Golebiewski M, Tiefenbach J, Peters MA, Brill B, Groner B, Bach I, Heinzel T, Göttlicher M. Krämer OH, et al. EMBO J. 2003 Jul 1;22(13):3411-20. doi: 10.1093/emboj/cdg315. EMBO J. 2003. PMID: 12840003 Free PMC article.

5

Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia.

Bug G, Ritter M, Wassmann B, Schoch C, Heinzel T, Schwarz K, Romanski A, Kramer OH, Kampfmann M, Hoelzer D, Neubauer A, Ruthardt M, Ottmann OG. Bug G, et al. Among authors: kramer oh. Cancer. 2005 Dec 15;104(12):2717-25. doi: 10.1002/cncr.21589. Cancer. 2005. PMID: 16294345 Free article. Clinical Trial.

6

Acetylation of Stat1 modulates NF-kappaB activity.

Krämer OH, Baus D, Knauer SK, Stein S, Jäger E, Stauber RH, Grez M, Pfitzner E, Heinzel T. Krämer OH, et al. Genes Dev. 2006 Feb 15;20(4):473-85. doi: 10.1101/gad.364306. Genes Dev. 2006. PMID: 16481475 Free PMC article.

7

Histone deacetylase inhibitors and hydroxyurea modulate the cell cycle and cooperatively induce apoptosis.

Krämer OH, Knauer SK, Zimmermann D, Stauber RH, Heinzel T. Krämer OH, et al. Oncogene. 2008 Jan 31;27(6):732-40. doi: 10.1038/sj.onc.1210677. Epub 2007 Jul 23. Oncogene. 2008. PMID: 17653085

8

Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha.

Krämer OH, Müller S, Buchwald M, Reichardt S, Heinzel T. Krämer OH, et al. FASEB J. 2008 May;22(5):1369-79. doi: 10.1096/fj.06-8050com. Epub 2007 Dec 11. FASEB J. 2008. PMID: 18073335

9

Acetylation of non-histone proteins modulates cellular signalling at multiple levels.

Spange S, Wagner T, Heinzel T, Krämer OH. Spange S, et al. Among authors: kramer oh. Int J Biochem Cell Biol. 2009 Jan;41(1):185-98. doi: 10.1016/j.biocel.2008.08.027. Epub 2008 Sep 2. Int J Biochem Cell Biol. 2009. PMID: 18804549 Review.

10

A phosphorylation-acetylation switch regulates STAT1 signaling.

Krämer OH, Knauer SK, Greiner G, Jandt E, Reichardt S, Gührs KH, Stauber RH, Böhmer FD, Heinzel T. Krämer OH, et al. Genes Dev. 2009 Jan 15;23(2):223-35. doi: 10.1101/gad.479209. Genes Dev. 2009. PMID: 19171783 Free PMC article.

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