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A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.
van der Schaar HM, Leyssen P, Thibaut HJ, de Palma A, van der Linden L, Lanke KH, Lacroix C, Verbeken E, Conrath K, Macleod AM, Mitchell DR, Palmer NJ, van de Poël H, Andrews M, Neyts J, van Kuppeveld FJ. van der Schaar HM, et al. Among authors: van der linden l, van de poel h, van kuppeveld fj. Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81. doi: 10.1128/AAC.01175-13. Epub 2013 Jul 29. Antimicrob Agents Chemother. 2013. PMID: 23896472 Free PMC article.
Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.
Strating JR, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, Leyssen P, van der Schaar HM, Lanke KH, Thibaut HJ, Ulferts R, Drin G, Schlinck N, Wubbolts RW, Sever N, Head SA, Liu JO, Beachy PA, De Matteis MA, Shair MD, Olkkonen VM, Neyts J, van Kuppeveld FJ. Strating JR, et al. Among authors: van der linden l, van der schaar hm, van kuppeveld fj. Cell Rep. 2015 Feb 3;10(4):600-15. doi: 10.1016/j.celrep.2014.12.054. Epub 2015 Jan 29. Cell Rep. 2015. PMID: 25640182 Free PMC article.
Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.
Ulferts R, van der Linden L, Thibaut HJ, Lanke KH, Leyssen P, Coutard B, De Palma AM, Canard B, Neyts J, van Kuppeveld FJ. Ulferts R, et al. Among authors: van der linden l, van kuppeveld fj. Antimicrob Agents Chemother. 2013 Apr;57(4):1952-6. doi: 10.1128/AAC.02084-12. Epub 2013 Jan 18. Antimicrob Agents Chemother. 2013. PMID: 23335743 Free PMC article.
Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.
van der Linden L, Ulferts R, Nabuurs SB, Kusov Y, Liu H, George S, Lacroix C, Goris N, Lefebvre D, Lanke KH, De Clercq K, Hilgenfeld R, Neyts J, van Kuppeveld FJ. van der Linden L, et al. Among authors: van kuppeveld fj. Antiviral Res. 2014 Mar;103:17-24. doi: 10.1016/j.antiviral.2013.12.012. Epub 2014 Jan 4. Antiviral Res. 2014. PMID: 24393668 Free PMC article.
Binding of glutathione to enterovirus capsids is essential for virion morphogenesis.
Thibaut HJ, van der Linden L, Jiang P, Thys B, Canela MD, Aguado L, Rombaut B, Wimmer E, Paul A, Pérez-Pérez MJ, van Kuppeveld FJ, Neyts J. Thibaut HJ, et al. Among authors: van der linden l, van kuppeveld fj. PLoS Pathog. 2014 Apr 10;10(4):e1004039. doi: 10.1371/journal.ppat.1004039. eCollection 2014 Apr. PLoS Pathog. 2014. PMID: 24722756 Free PMC article.
The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.
van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ. van der Linden L, et al. Among authors: van kuppeveld fj. PLoS Pathog. 2015 Mar 23;11(3):e1004733. doi: 10.1371/journal.ppat.1004733. eCollection 2015 Mar. PLoS Pathog. 2015. PMID: 25799064 Free PMC article.
Replication and Inhibitors of Enteroviruses and Parechoviruses.
van der Linden L, Wolthers KC, van Kuppeveld FJ. van der Linden L, et al. Among authors: van kuppeveld fj. Viruses. 2015 Aug 10;7(8):4529-62. doi: 10.3390/v7082832. Viruses. 2015. PMID: 26266417 Free PMC article. Review.
158 results