Letai A - Search Results

1

Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia.

Davids MS, Deng J, Wiestner A, Lannutti BJ, Wang L, Wu CJ, Wilson WH, Brown JR, Letai A. Davids MS, et al. Among authors: letai a. Blood. 2012 Oct 25;120(17):3501-9. doi: 10.1182/blood-2012-02-414060. Epub 2012 Sep 5. Blood. 2012. PMID: 22955911 Free PMC article.

2

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.

Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A. Certo M, et al. Among authors: letai a. Cancer Cell. 2006 May;9(5):351-65. doi: 10.1016/j.ccr.2006.03.027. Cancer Cell. 2006. PMID: 16697956 Free article.

3

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

Del Gaizo Moore V, Brown JR, Certo M, Love TM, Novina CD, Letai A. Del Gaizo Moore V, et al. Among authors: letai a. J Clin Invest. 2007 Jan;117(1):112-21. doi: 10.1172/JCI28281. J Clin Invest. 2007. PMID: 17200714 Free PMC article.

4

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents.

Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A. Deng J, et al. Among authors: letai a. Cancer Cell. 2007 Aug;12(2):171-85. doi: 10.1016/j.ccr.2007.07.001. Cancer Cell. 2007. PMID: 17692808 Free article.

5

BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.

Del Gaizo Moore V, Schlis KD, Sallan SE, Armstrong SA, Letai A. Del Gaizo Moore V, et al. Among authors: letai a. Blood. 2008 Feb 15;111(4):2300-9. doi: 10.1182/blood-2007-06-098012. Epub 2007 Dec 4. Blood. 2008. PMID: 18056841 Free PMC article.

6

Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion.

Deng J, Shimamura T, Perera S, Carlson NE, Cai D, Shapiro GI, Wong KK, Letai A. Deng J, et al. Among authors: letai a. Cancer Res. 2007 Dec 15;67(24):11867-75. doi: 10.1158/0008-5472.CAN-07-1961. Cancer Res. 2007. PMID: 18089817

7

Rational design of therapeutics targeting the BCL-2 family: are some cancer cells primed for death but waiting for a final push?

Del Gaizo Moore V, Letai A. Del Gaizo Moore V, et al. Among authors: letai a. Adv Exp Med Biol. 2008;615:159-75. doi: 10.1007/978-1-4020-6554-5_8. Adv Exp Med Biol. 2008. PMID: 18437895 Review.

8

Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737.

Kutuk O, Letai A. Kutuk O, et al. Among authors: letai a. Cancer Res. 2008 Oct 1;68(19):7985-94. doi: 10.1158/0008-5472.CAN-08-1418. Cancer Res. 2008. PMID: 18829556 Free PMC article.

9

Control of mitochondrial apoptosis by the Bcl-2 family.

Brunelle JK, Letai A. Brunelle JK, et al. Among authors: letai a. J Cell Sci. 2009 Feb 15;122(Pt 4):437-41. doi: 10.1242/jcs.031682. J Cell Sci. 2009. PMID: 19193868 Free PMC article. Review. No abstract available.

10

Hiding from ABT-737 in lymph nodes.

Letai A. Letai A. Blood. 2009 Apr 30;113(18):4132-3. doi: 10.1182/blood-2008-12-192831. Blood. 2009. PMID: 19406997 Free article. No abstract available.

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