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Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Yoshida T, Akahoshi F, Sakashita H, Kitajima H, Nakamura M, Sonda S, Takeuchi M, Tanaka Y, Ueda N, Sekiguchi S, Ishige T, Shima K, Nabeno M, Abe Y, Anabuki J, Soejima A, Yoshida K, Takashina Y, Ishii S, Kiuchi S, Fukuda S, Tsutsumiuchi R, Kosaka K, Murozono T, Nakamaru Y, Utsumi H, Masutomi N, Kishida H, Miyaguchi I, Hayashi Y. Yoshida T, et al. Among authors: kitajima h. Bioorg Med Chem. 2012 Oct 1;20(19):5705-19. doi: 10.1016/j.bmc.2012.08.012. Epub 2012 Aug 17. Bioorg Med Chem. 2012. PMID: 22959556
Epigenetic silencing of SMOC1 in traditional serrated adenoma and colorectal cancer.
Aoki H, Yamamoto E, Takasawa A, Niinuma T, Yamano HO, Harada T, Matsushita HO, Yoshikawa K, Takagi R, Harada E, Tanaka Y, Yoshida Y, Aoyama T, Eizuka M, Yorozu A, Kitajima H, Kai M, Sawada N, Sugai T, Nakase H, Suzuki H. Aoki H, et al. Among authors: kitajima h. Oncotarget. 2017 Dec 20;9(4):4707-4721. doi: 10.18632/oncotarget.23523. eCollection 2018 Jan 12. Oncotarget. 2017. PMID: 29435136 Free PMC article.
Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors.
Harada T, Yamamoto E, Yamano HO, Aoki H, Matsushita HO, Yoshikawa K, Takagi R, Harada E, Tanaka Y, Yoshida Y, Eizuka M, Yorozu A, Sudo G, Kitajima H, Niinuma T, Kai M, Sasaki Y, Tokino T, Sugai T, Nakase H, Suzuki H. Harada T, et al. Among authors: kitajima h. J Gastroenterol. 2018 Dec;53(12):1241-1252. doi: 10.1007/s00535-018-1481-z. Epub 2018 Jun 11. J Gastroenterol. 2018. PMID: 29948303
Regulatory roles of claudin-1 in cell adhesion and microvilli formation.
Takasawa K, Takasawa A, Akimoto T, Magara K, Aoyama T, Kitajima H, Murakami T, Ono Y, Kyuno D, Suzuki H, Osanai M. Takasawa K, et al. Among authors: kitajima h. Biochem Biophys Res Commun. 2021 Aug 6;565:36-42. doi: 10.1016/j.bbrc.2021.05.070. Epub 2021 Jun 2. Biochem Biophys Res Commun. 2021. PMID: 34090208
Subtypes of the Type II Pit Pattern Reflect Distinct Molecular Subclasses in the Serrated Neoplastic Pathway.
Aoki H, Yamamoto E, Yamano HO, Sugai T, Kimura T, Tanaka Y, Matsushita HO, Yoshikawa K, Takagi R, Harada E, Nakaoka M, Yoshida Y, Harada T, Sudo G, Eizuka M, Yorozu A, Kitajima H, Niinuma T, Kai M, Nojima M, Suzuki H, Nakase H. Aoki H, et al. Among authors: kitajima h. Dig Dis Sci. 2018 Jul;63(7):1920-1928. doi: 10.1007/s10620-018-5016-5. Epub 2018 Mar 15. Dig Dis Sci. 2018. PMID: 29546645
345 results