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Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence.
Sidique S, Dhanya RP, Sheffler DJ, Nickols HH, Yang L, Dahl R, Mangravita-Novo A, Smith LH, D'Souza MS, Semenova S, Conn PJ, Markou A, Cosford ND. Sidique S, et al. Among authors: semenova s. J Med Chem. 2012 Nov 26;55(22):9434-45. doi: 10.1021/jm3005306. Epub 2012 Oct 23. J Med Chem. 2012. PMID: 23009245 Free PMC article.
The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats.
Jin X, Semenova S, Yang L, Ardecky R, Sheffler DJ, Dahl R, Conn PJ, Cosford ND, Markou A. Jin X, et al. Among authors: semenova s. Neuropsychopharmacology. 2010 Sep;35(10):2021-36. doi: 10.1038/npp.2010.82. Epub 2010 Jun 16. Neuropsychopharmacology. 2010. PMID: 20555310 Free PMC article.
Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats.
Dhanya RP, Sidique S, Sheffler DJ, Nickols HH, Herath A, Yang L, Dahl R, Ardecky R, Semenova S, Markou A, Conn PJ, Cosford ND. Dhanya RP, et al. Among authors: semenova s. J Med Chem. 2011 Jan 13;54(1):342-53. doi: 10.1021/jm1012165. Epub 2010 Dec 14. J Med Chem. 2011. PMID: 21155570 Free PMC article.
170 results