Ploeger B - Search Results

1

Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease.

Jeppsson F, Eketjäll S, Janson J, Karlström S, Gustavsson S, Olsson LL, Radesäter AC, Ploeger B, Cebers G, Kolmodin K, Swahn BM, von Berg S, Bueters T, Fälting J. Jeppsson F, et al. Among authors: ploeger b. J Biol Chem. 2012 Nov 30;287(49):41245-57. doi: 10.1074/jbc.M112.409110. Epub 2012 Oct 9. J Biol Chem. 2012. PMID: 23048024 Free PMC article.

2

The virtue of translational PKPD modeling in drug discovery: selecting the right clinical candidate while sparing animal lives.

Bueters T, Ploeger BA, Visser SA. Bueters T, et al. Drug Discov Today. 2013 Sep;18(17-18):853-62. doi: 10.1016/j.drudis.2013.05.001. Epub 2013 May 9. Drug Discov Today. 2013. PMID: 23665277 Review.

3

Modeling of age-dependent amyloid accumulation and γ-secretase inhibition of soluble and insoluble Aβ in a transgenic mouse model of amyloid deposition.

Parkinson J, Ploeger B, Appelkvist P, Bogstedt A, Dillner Bergstedt K, Eketjäll S, Visser SA. Parkinson J, et al. Among authors: ploeger b. Pharmacol Res Perspect. 2013 Dec;1(2):e00012. doi: 10.1002/prp2.12. Epub 2013 Dec 5. Pharmacol Res Perspect. 2013. PMID: 25505567 Free PMC article.

4

Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico-in vivo extrapolation and physiologically-based pharmacokinetic modeling approach.

Malmborg J, Ploeger BA. Malmborg J, et al. J Pharmacol Toxicol Methods. 2013 May-Jun;67(3):203-13. doi: 10.1016/j.vascn.2012.12.002. Epub 2012 Dec 29. J Pharmacol Toxicol Methods. 2013. PMID: 23280406

5

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.

Danhof M, de Lange EC, Della Pasqua OE, Ploeger BA, Voskuyl RA. Danhof M, et al. Trends Pharmacol Sci. 2008 Apr;29(4):186-91. doi: 10.1016/j.tips.2008.01.007. Epub 2008 Mar 18. Trends Pharmacol Sci. 2008. PMID: 18353445 Review.

6

Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling.

Ploeger BA, van der Graaf PH, Danhof M. Ploeger BA, et al. Drug Metab Pharmacokinet. 2009;24(1):3-15. doi: 10.2133/dmpk.24.3. Drug Metab Pharmacokinet. 2009. PMID: 19252332 Free article. Review.

7

Modeling and Simulation of In Vivo Drug Effects.

Lippert J, Burghaus R, Kuepfer L, Ploeger B, Schaller S, Schmitt W, Willmann S. Lippert J, et al. Among authors: ploeger b. Handb Exp Pharmacol. 2016;232:313-29. doi: 10.1007/164_2015_21. Handb Exp Pharmacol. 2016. PMID: 26578524 Review.

8

Physiologically based pharmacokinetic modeling to investigate regional brain distribution kinetics in rats.

Westerhout J, Ploeger B, Smeets J, Danhof M, de Lange EC. Westerhout J, et al. Among authors: ploeger b. AAPS J. 2012 Sep;14(3):543-53. doi: 10.1208/s12248-012-9366-1. Epub 2012 May 17. AAPS J. 2012. PMID: 22588644 Free PMC article. Review.

9

Application of the convection-dispersion equation to modelling oral drug absorption.

Freijer JI, Post TM, Ploeger BA, DeJongh J, Danhof M. Freijer JI, et al. Bull Math Biol. 2007 Jan;69(1):181-95. doi: 10.1007/s11538-006-9122-8. Epub 2006 Oct 6. Bull Math Biol. 2007. PMID: 17024551 Free PMC article.

10

Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis.

Danhof M, de Jongh J, De Lange EC, Della Pasqua O, Ploeger BA, Voskuyl RA. Danhof M, et al. Annu Rev Pharmacol Toxicol. 2007;47:357-400. doi: 10.1146/annurev.pharmtox.47.120505.105154. Annu Rev Pharmacol Toxicol. 2007. PMID: 17067280 Review.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

65 results

Search Page

Filters