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Design, synthesis, and studies of small molecule STAT3 inhibitors.
Bhasin D, Cisek K, Pandharkar T, Regan N, Li C, Pandit B, Lin J, Li PK. Bhasin D, et al. Among authors: li c, li pk. Bioorg Med Chem Lett. 2008 Jan 1;18(1):391-5. doi: 10.1016/j.bmcl.2007.10.031. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2008. PMID: 18006313
New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells.
Lin L, Hutzen B, Ball S, Foust E, Sobo M, Deangelis S, Pandit B, Friedman L, Li C, Li PK, Fuchs J, Lin J. Lin L, et al. Among authors: li c, li pk. Cancer Sci. 2009 Sep;100(9):1719-27. doi: 10.1111/j.1349-7006.2009.01220.x. Epub 2009 May 18. Cancer Sci. 2009. PMID: 19558577 Free PMC article.
The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.
Bill MA, Fuchs JR, Li C, Yui J, Bakan C, Benson DM Jr, Schwartz EB, Abdelhamid D, Lin J, Hoyt DG, Fossey SL, Young GS, Carson WE 3rd, Li PK, Lesinski GB. Bill MA, et al. Among authors: li c, li pk. Mol Cancer. 2010 Jun 25;9:165. doi: 10.1186/1476-4598-9-165. Mol Cancer. 2010. PMID: 20576164 Free PMC article.
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