Keung W - Search Results

1

Inhibition of malonyl-CoA decarboxylase reduces the inflammatory response associated with insulin resistance.

Samokhvalov V, Ussher JR, Fillmore N, Armstrong IK, Keung W, Moroz D, Lopaschuk DG, Seubert J, Lopaschuk GD. Samokhvalov V, et al. Among authors: keung w. Am J Physiol Endocrinol Metab. 2012 Dec 15;303(12):E1459-68. doi: 10.1152/ajpendo.00018.2012. Epub 2012 Oct 16. Am J Physiol Endocrinol Metab. 2012. PMID: 23074239 Free article.

2

Role of the atypical protein kinase Czeta in regulation of 5'-AMP-activated protein kinase in cardiac and skeletal muscle.

Ussher JR, Jaswal JS, Wagg CS, Armstrong HE, Lopaschuk DG, Keung W, Lopaschuk GD. Ussher JR, et al. Among authors: keung w. Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E349-57. doi: 10.1152/ajpendo.00009.2009. Am J Physiol Endocrinol Metab. 2009. PMID: 19625676 Free article.

3

Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle.

Zhang L, Keung W, Samokhvalov V, Wang W, Lopaschuk GD. Zhang L, et al. Among authors: keung w. Biochim Biophys Acta. 2010 Jan;1801(1):1-22. doi: 10.1016/j.bbalip.2009.09.014. Epub 2009 Sep 24. Biochim Biophys Acta. 2010. PMID: 19782765 Review.

4

Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.

Ussher JR, Koves TR, Cadete VJ, Zhang L, Jaswal JS, Swyrd SJ, Lopaschuk DG, Proctor SD, Keung W, Muoio DM, Lopaschuk GD. Ussher JR, et al. Among authors: keung w. Diabetes. 2010 Oct;59(10):2453-64. doi: 10.2337/db09-1293. Epub 2010 Jun 3. Diabetes. 2010. PMID: 20522596 Free PMC article.

5

Chronic central leptin decreases food intake and improves glucose tolerance in diet-induced obese mice independent of hypothalamic malonyl CoA levels and skeletal muscle insulin sensitivity.

Keung W, Palaniyappan A, Lopaschuk GD. Keung W, et al. Endocrinology. 2011 Nov;152(11):4127-37. doi: 10.1210/en.2011-1254. Epub 2011 Sep 13. Endocrinology. 2011. PMID: 21914780

6

Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance.

Ussher JR, Folmes CD, Keung W, Fillmore N, Jaswal JS, Cadete VJ, Beker DL, Lam VH, Zhang L, Lopaschuk GD. Ussher JR, et al. Among authors: keung w. PLoS One. 2012;7(5):e37703. doi: 10.1371/journal.pone.0037703. Epub 2012 May 22. PLoS One. 2012. PMID: 22629445 Free PMC article.

7

Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice.

Keung W, Ussher JR, Jaswal JS, Raubenheimer M, Lam VH, Wagg CS, Lopaschuk GD. Keung W, et al. Diabetes. 2013 Mar;62(3):711-20. doi: 10.2337/db12-0259. Epub 2012 Nov 8. Diabetes. 2013. PMID: 23139350 Free PMC article.

8

Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice.

Ussher JR, Keung W, Fillmore N, Koves TR, Mori J, Zhang L, Lopaschuk DG, Ilkayeva OR, Wagg CS, Jaswal JS, Muoio DM, Lopaschuk GD. Ussher JR, et al. Among authors: keung w. J Pharmacol Exp Ther. 2014 Jun;349(3):487-96. doi: 10.1124/jpet.114.214197. Epub 2014 Apr 3. J Pharmacol Exp Ther. 2014. PMID: 24700885 Free PMC article.

9

Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat.

Fillmore N, Keung W, Kelly SE, Proctor SD, Lopaschuk GD, Ussher JR. Fillmore N, et al. Among authors: keung w. Exp Physiol. 2015 Jun;100(6):730-41. doi: 10.1113/EP085052. Epub 2015 May 14. Exp Physiol. 2015. PMID: 25786668 Free article.

10

Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice.

Ussher JR, Fillmore N, Keung W, Zhang L, Mori J, Sidhu VK, Fukushima A, Gopal K, Lopaschuk DG, Wagg CS, Jaswal JS, Dyck JR, Lopaschuk GD. Ussher JR, et al. Among authors: keung w. Diabetes. 2016 Jul;65(7):1883-91. doi: 10.2337/db15-1145. Epub 2016 May 13. Diabetes. 2016. PMID: 27207536

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