Wang H - Search Results

1

Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches.

Lynch C, Pan Y, Li L, Ferguson SS, Xia M, Swaan PW, Wang H. Lynch C, et al. Among authors: wang h. Pharm Res. 2013 Feb;30(2):489-501. doi: 10.1007/s11095-012-0895-1. Epub 2012 Oct 23. Pharm Res. 2013. PMID: 23090669 Free PMC article.

2

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.

Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL. Wang H, et al. J Biol Chem. 2003 Apr 18;278(16):14146-52. doi: 10.1074/jbc.M212482200. Epub 2003 Feb 5. J Biol Chem. 2003. PMID: 12571232 Free article.

3

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.

Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E. Wang H, et al. J Biol Chem. 2004 Jul 9;279(28):29295-301. doi: 10.1074/jbc.M400580200. Epub 2004 Apr 28. J Biol Chem. 2004. PMID: 15123723 Free article.

4

Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.

Faucette SR, Sueyoshi T, Smith CM, Negishi M, Lecluyse EL, Wang H. Faucette SR, et al. Among authors: wang h. J Pharmacol Exp Ther. 2006 Jun;317(3):1200-9. doi: 10.1124/jpet.105.098160. Epub 2006 Mar 2. J Pharmacol Exp Ther. 2006. PMID: 16513849

5

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers.

Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H. Faucette SR, et al. Among authors: wang h. J Pharmacol Exp Ther. 2007 Jan;320(1):72-80. doi: 10.1124/jpet.106.112136. Epub 2006 Oct 13. J Pharmacol Exp Ther. 2007. PMID: 17041008 Free PMC article.

6

The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor.

Li L, Chen T, Stanton JD, Sueyoshi T, Negishi M, Wang H. Li L, et al. Among authors: wang h. Mol Pharmacol. 2008 Aug;74(2):443-53. doi: 10.1124/mol.108.046656. Epub 2008 May 20. Mol Pharmacol. 2008. PMID: 18492798 Free PMC article.

7

CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme.

Wang H, Tompkins LM. Wang H, et al. Curr Drug Metab. 2008 Sep;9(7):598-610. doi: 10.2174/138920008785821710. Curr Drug Metab. 2008. PMID: 18781911 Free PMC article. Review.

8

Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways.

Li L, Stanton JD, Tolson AH, Luo Y, Wang H. Li L, et al. Among authors: wang h. Pharm Res. 2009 Apr;26(4):872-82. doi: 10.1007/s11095-008-9788-8. Epub 2008 Nov 26. Pharm Res. 2009. PMID: 19034627 Free PMC article.

9

Nuclear translocation of adenoviral-enhanced yellow fluorescent protein-tagged-human constitutive androstane receptor (hCAR): a novel tool for screening hCAR activators in human primary hepatocytes.

Li H, Chen T, Cottrell J, Wang H. Li H, et al. Among authors: wang h. Drug Metab Dispos. 2009 May;37(5):1098-106. doi: 10.1124/dmd.108.026005. Epub 2009 Feb 5. Drug Metab Dispos. 2009. PMID: 19196842 Free PMC article.

10

Methadone induces the expression of hepatic drug-metabolizing enzymes through the activation of pregnane X receptor and constitutive androstane receptor.

Tolson AH, Li H, Eddington ND, Wang H. Tolson AH, et al. Among authors: wang h. Drug Metab Dispos. 2009 Sep;37(9):1887-94. doi: 10.1124/dmd.109.027854. Epub 2009 Jun 11. Drug Metab Dispos. 2009. PMID: 19520773 Free PMC article.

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