Wang ZR - Search Results

1

Identification of novel anaplastic lymphoma kinase (ALK) inhibitors using a common feature pharmacophore model derived from known ligands crystallized with ALK.

Xie HZ, Lan H, Pan YL, Zou J, Wang ZR, Li LL, Huang Q, Zhang H, Yang SY. Xie HZ, et al. Among authors: wang zr. Chem Biol Drug Des. 2013 Feb;81(2):175-84. doi: 10.1111/cbdd.12084. Epub 2012 Nov 27. Chem Biol Drug Des. 2013. PMID: 23107363

2

Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain.

Zeng XF, Li WW, Fan HJ, Wang XY, Ji P, Wang ZR, Ma S, Li LL, Ma XF, Yang SY. Zeng XF, et al. Among authors: wang xy, wang zr. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4742-4. doi: 10.1016/j.bmcl.2011.06.075. Epub 2011 Jun 23. Bioorg Med Chem Lett. 2011. PMID: 21752639

3

Systems biology modeling reveals a possible mechanism of the tumor cell death upon oncogene inactivation in EGFR addicted cancers.

Zhou JP, Chen X, Feng S, Luo SD, Pan YL, Zhong L, Ji P, Wang ZR, Ma S, Li LL, Wei YQ, Yang SY. Zhou JP, et al. Among authors: wang zr. PLoS One. 2011;6(12):e28930. doi: 10.1371/journal.pone.0028930. Epub 2011 Dec 14. PLoS One. 2011. PMID: 22194952 Free PMC article.

4

SKLB1206, a novel orally available multikinase inhibitor targeting EGFR activating and T790M mutants, ErbB2, ErbB4, and VEGFR2, displays potent antitumor activity both in vitro and in vivo.

Pan Y, Xu Y, Feng S, Luo S, Zheng R, Yang J, Wang L, Zhong L, Yang HY, Wang BL, Yu Y, Liu J, Cao Z, Wang X, Ji P, Wang Z, Chen X, Zhang S, Wei YQ, Yang SY. Pan Y, et al. Mol Cancer Ther. 2012 Apr;11(4):952-62. doi: 10.1158/1535-7163.MCT-11-0679. Epub 2012 Feb 8. Mol Cancer Ther. 2012. PMID: 22319204

5

Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo.

Li WW, Wang XY, Zheng RL, Yan HX, Cao ZX, Zhong L, Wang ZR, Ji P, Yang LL, Wang LJ, Xu Y, Liu JJ, Yang J, Zhang CH, Ma S, Feng S, Sun QZ, Wei YQ, Yang SY. Li WW, et al. Among authors: wang lj, wang xy, wang zr. J Med Chem. 2012 Apr 26;55(8):3852-66. doi: 10.1021/jm300042x. Epub 2012 Apr 6. J Med Chem. 2012. PMID: 22452518

6

Discovery of novel Bruton's tyrosine kinase inhibitors using a hybrid protocol of virtual screening approaches based on SVM model, pharmacophore and molecular docking.

Wan HL, Wang ZR, Li LL, Cheng C, Ji P, Liu JJ, Zhang H, Zou J, Yang SY. Wan HL, et al. Among authors: wang zr. Chem Biol Drug Des. 2012 Sep;80(3):366-73. doi: 10.1111/j.1747-0285.2012.01415.x. Epub 2012 Jun 27. Chem Biol Drug Des. 2012. PMID: 22594639

7

Retrieving novel C5aR antagonists using a hybrid ligand-based virtual screening protocol based on SVM classification and pharmacophore models.

Qing XY, Zhang CH, Li LL, Ji P, Ma S, Wan HL, Wang ZR, Zou J, Yang SY. Qing XY, et al. Among authors: wang zr. J Biomol Struct Dyn. 2013;31(2):215-23. doi: 10.1080/07391102.2012.698245. Epub 2012 Jul 25. J Biomol Struct Dyn. 2013. PMID: 22831459

8

Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.

Yang LL, Li GB, Yan HX, Sun QZ, Ma S, Ji P, Wang ZR, Feng S, Zou J, Yang SY. Yang LL, et al. Among authors: wang zr. Eur J Med Chem. 2012 Oct;56:30-8. doi: 10.1016/j.ejmech.2012.08.007. Epub 2012 Aug 14. Eur J Med Chem. 2012. PMID: 22944772

9

Structural modification of an EGFR inhibitor that showed weak off-target activity against RET leading to the discovery of a potent RET inhibitor.

Sun QZ, Xu Y, Liu JJ, Zhang CH, Wang ZR, Zheng RL, Wang WJ, Li LL, Yang SY. Sun QZ, et al. Among authors: wang wj, wang zr. Mol Divers. 2014 May;18(2):403-9. doi: 10.1007/s11030-014-9508-8. Epub 2014 Feb 11. Mol Divers. 2014. PMID: 24515340

10

Melamine-tainted milk product-associated urinary stones in children.

Wang Z, Luo H, Tu W, Yang H, Wong WH, Wong WT, Yung KF, Zhou N, Zhang J, Li X, Wang Z, Guo W, Mu D, Li F, Mao M, Lau YL. Wang Z, et al. Pediatr Int. 2011 Aug;53(4):489-96. doi: 10.1111/j.1442-200X.2010.03284.x. Pediatr Int. 2011. PMID: 21040195

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