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The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response.
Lewis JP, Horenstein RB, Ryan K, O'Connell JR, Gibson Q, Mitchell BD, Tanner K, Chai S, Bliden KP, Tantry US, Peer CJ, Figg WD, Spencer SD, Pacanowski MA, Gurbel PA, Shuldiner AR. Lewis JP, et al. Among authors: pacanowski ma. Pharmacogenet Genomics. 2013 Jan;23(1):1-8. doi: 10.1097/FPC.0b013e32835aa8a2. Pharmacogenet Genomics. 2013. PMID: 23111421 Free PMC article.
The CYP2C19*17 variant is not independently associated with clopidogrel response.
Lewis JP, Stephens SH, Horenstein RB, O'Connell JR, Ryan K, Peer CJ, Figg WD, Spencer SD, Pacanowski MA, Mitchell BD, Shuldiner AR. Lewis JP, et al. Among authors: pacanowski ma. J Thromb Haemost. 2013 Sep;11(9):1640-6. doi: 10.1111/jth.12342. J Thromb Haemost. 2013. PMID: 23809542 Free PMC article.
Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers.
Horenstein RB, Madabushi R, Zineh I, Yerges-Armstrong LM, Peer CJ, Schuck RN, Figg WD, Shuldiner AR, Pacanowski MA. Horenstein RB, et al. Among authors: pacanowski ma. J Clin Pharmacol. 2014 Aug;54(8):865-73. doi: 10.1002/jcph.293. Epub 2014 Apr 7. J Clin Pharmacol. 2014. PMID: 24710841 Free PMC article. Clinical Trial.
A sensitive and rapid ultra HPLC-MS/MS method for the simultaneous detection of clopidogrel and its derivatized active thiol metabolite in human plasma.
Peer CJ, Spencer SD, VanDenBerg DA, Pacanowski MA, Horenstein RB, Figg WD. Peer CJ, et al. Among authors: pacanowski ma. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jan 1;880(1):132-9. doi: 10.1016/j.jchromb.2011.11.029. Epub 2011 Nov 26. J Chromatogr B Analyt Technol Biomed Life Sci. 2012. PMID: 22169056 Free PMC article.
64 results