John-Baptiste A - Search Results

1

Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug-drug interaction.

Palmer C, Pairish M, Kephart S, Bouzida D, Cui J, Deal J, Dong L, Gu D, Linton A, McAlpine I, Yamazaki S, Smith E, John-Baptiste A, Bagrodia S, Kania R, Guo C. Palmer C, et al. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7605-9. doi: 10.1016/j.bmcl.2012.10.011. Epub 2012 Oct 11. Bioorg Med Chem Lett. 2012. PMID: 23116892

2

Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901.

Torti VR, Wojciechowicz D, Hu W, John-Baptiste A, Evering W, Troche G, Marroquin LD, Smeal T, Yamazaki S, Palmer CL, Burns-Naas LA, Bagrodia S. Torti VR, et al. Mol Cancer Ther. 2012 Oct;11(10):2274-83. doi: 10.1158/1535-7163.MCT-11-0984. Epub 2012 Jul 2. Mol Cancer Ther. 2012. PMID: 22752429

3

Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation.

Fang DD, Zhang CC, Gu Y, Jani JP, Cao J, Tsaparikos K, Yuan J, Thiel M, Jackson-Fisher A, Zong Q, Lappin PB, Hayashi T, Schwab RB, Wong A, John-Baptiste A, Bagrodia S, Los G, Bender S, Christensen J, Vanarsdale T. Fang DD, et al. PLoS One. 2013 Jun 27;8(6):e67258. doi: 10.1371/journal.pone.0067258. Print 2013. PLoS One. 2013. PMID: 23826249 Free PMC article.

4

Transient knock down of checkpoint kinase 1 in hematopoietic progenitors is linked to bone marrow toxicity.

Hu W, Zong Q, John-Baptiste A, Jessen B. Hu W, et al. Toxicol Lett. 2011 Jul 28;204(2-3):141-7. doi: 10.1016/j.toxlet.2011.04.025. Epub 2011 Apr 30. Toxicol Lett. 2011. PMID: 21557990

5

Evaluation of miR-216a and miR-217 as Potential Biomarkers of Acute Exocrine Pancreatic Toxicity in Rats.

Wang J, Huang W, Thibault S, Brown TP, Bobrowski W, Gukasyan HJ, Evering W, Hu W, John-Baptiste A, Vitsky A. Wang J, et al. Toxicol Pathol. 2017 Feb;45(2):321-334. doi: 10.1177/0192623316678090. Epub 2016 Dec 26. Toxicol Pathol. 2017. PMID: 28013573

6

Comparison of 3 kidney injury multiplex panels in rats.

John-Baptiste A, Vitsky A, Sace F, Zong Q, Ko M, Yafawi R, Liu L. John-Baptiste A, et al. Int J Toxicol. 2012 Nov-Dec;31(6):529-36. doi: 10.1177/1091581812463348. Epub 2012 Nov 1. Int J Toxicol. 2012. PMID: 23117654

7

Synergistic effect of the γ-secretase inhibitor PF-03084014 and docetaxel in breast cancer models.

Zhang CC, Yan Z, Zong Q, Fang DD, Painter C, Zhang Q, Chen E, Lira ME, John-Baptiste A, Christensen JG. Zhang CC, et al. Stem Cells Transl Med. 2013 Mar;2(3):233-42. doi: 10.5966/sctm.2012-0096. Epub 2013 Feb 13. Stem Cells Transl Med. 2013. PMID: 23408105 Free PMC article.

8

Sunitinib, a receptor tyrosine kinase inhibitor, increases blood pressure in rats without associated changes in cardiac structure and function.

Blasi E, Heyen J, Patyna S, Hemkens M, Ramirez D, John-Baptiste A, Steidl-Nichols J, McHarg A. Blasi E, et al. Cardiovasc Ther. 2012 Oct;30(5):287-94. doi: 10.1111/j.1755-5922.2011.00278.x. Epub 2011 May 31. Cardiovasc Ther. 2012. PMID: 21884012 Free article.

9

Effects of CP-532,623 and torcetrapib, cholesteryl ester transfer protein inhibitors, on arterial blood pressure.

Blasi E, Bamberger M, Knight D, Engwall M, Wolk R, Winter S, Betts A, John-Baptiste A, Keiser J. Blasi E, et al. J Cardiovasc Pharmacol. 2009 Jun;53(6):507-16. doi: 10.1097/FJC.0b013e3181a8184c. J Cardiovasc Pharmacol. 2009. PMID: 19455053 Clinical Trial.

10

Evaluation of potential gastrointestinal biomarkers in a PAK4 inhibitor-treated preclinical toxicity model to address unmonitorable gastrointestinal toxicity.

John-Baptiste A, Huang W, Kindt E, Wu A, Vitsky A, Scott W, Gross C, Yang AH, Schaiff WT, Ramaiah SK. John-Baptiste A, et al. Toxicol Pathol. 2012 Apr;40(3):482-90. doi: 10.1177/0192623311432289. Epub 2012 Mar 6. Toxicol Pathol. 2012. PMID: 22395791

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