Smith E - Search Results

1

Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug-drug interaction.

Palmer C, Pairish M, Kephart S, Bouzida D, Cui J, Deal J, Dong L, Gu D, Linton A, McAlpine I, Yamazaki S, Smith E, John-Baptiste A, Bagrodia S, Kania R, Guo C. Palmer C, et al. Among authors: smith e. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7605-9. doi: 10.1016/j.bmcl.2012.10.011. Epub 2012 Oct 11. Bioorg Med Chem Lett. 2012. PMID: 23116892

2

Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.

Zehnder L, Bennett M, Meng J, Huang B, Ninkovic S, Wang F, Braganza J, Tatlock J, Jewell T, Zhou JZ, Burke B, Wang J, Maegley K, Mehta PP, Yin MJ, Gajiwala KS, Hickey MJ, Yamazaki S, Smith E, Kang P, Sistla A, Dovalsantos E, Gehring MR, Kania R, Wythes M, Kung PP. Zehnder L, et al. Among authors: smith e. J Med Chem. 2011 May 12;54(9):3368-85. doi: 10.1021/jm200128m. Epub 2011 Apr 20. J Med Chem. 2011. PMID: 21438541

3

Metabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects.

Johnson TR, Tan W, Goulet L, Smith EB, Yamazaki S, Walker GS, O'Gorman MT, Bedarida G, Zou HY, Christensen JG, Nguyen LN, Shen Z, Dalvie D, Bello A, Smith BJ. Johnson TR, et al. Xenobiotica. 2015 Jan;45(1):45-59. doi: 10.3109/00498254.2014.941964. Epub 2014 Jul 18. Xenobiotica. 2015. PMID: 25034009

4

In vitro metabolic activation of thiabendazole via 5-hydroxythiabendazole: identification of a glutathione conjugate of 5-hydroxythiabendazole.

Dalvie D, Smith E, Deese A, Bowlin S. Dalvie D, et al. Among authors: smith e. Drug Metab Dispos. 2006 Apr;34(4):709-17. doi: 10.1124/dmd.105.008094. Epub 2006 Jan 24. Drug Metab Dispos. 2006. PMID: 16434547

5

Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.

Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA. Dalvie D, et al. Among authors: smith e, smith da. Chem Res Toxicol. 2009 Feb;22(2):357-68. doi: 10.1021/tx8004357. Chem Res Toxicol. 2009. PMID: 19146377

6

Bioactivation of lumiracoxib by peroxidases and human liver microsomes: identification of multiple quinone imine intermediates and GSH adducts.

Kang P, Dalvie D, Smith E, Renner M. Kang P, et al. Among authors: smith e. Chem Res Toxicol. 2009 Jan;22(1):106-17. doi: 10.1021/tx8002356. Chem Res Toxicol. 2009. PMID: 19063590

7

Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes.

Kang P, Dalvie D, Smith E, Zhou S, Deese A. Kang P, et al. Among authors: smith e. Drug Metab Dispos. 2007 Jul;35(7):1081-8. doi: 10.1124/dmd.107.014860. Epub 2007 Apr 2. Drug Metab Dispos. 2007. PMID: 17403914

8

NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.

Zhao SX, Dalvie DK, Kelly JM, Soglia JR, Frederick KS, Smith EB, Obach RS, Kalgutkar AS. Zhao SX, et al. Chem Res Toxicol. 2007 Nov;20(11):1649-57. doi: 10.1021/tx700132x. Epub 2007 Oct 2. Chem Res Toxicol. 2007. PMID: 17907785

9

Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.

Lee CA, Jones JP 3rd, Katayama J, Kaspera R, Jiang Y, Freiwald S, Smith E, Walker GS, Totah RA. Lee CA, et al. Among authors: smith e. Drug Metab Dispos. 2012 May;40(5):943-51. doi: 10.1124/dmd.111.043505. Epub 2012 Feb 10. Drug Metab Dispos. 2012. PMID: 22328583 Free PMC article.

10

Bioactivation of flutamide metabolites by human liver microsomes.

Kang P, Dalvie D, Smith E, Zhou S, Deese A, Nieman JA. Kang P, et al. Among authors: smith e. Drug Metab Dispos. 2008 Jul;36(7):1425-37. doi: 10.1124/dmd.108.020370. Epub 2008 Apr 14. Drug Metab Dispos. 2008. PMID: 18411402

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