Humphreys WG - Search Results

1

Bioactivation of 2-(alkylthio)-1,3,4-thiadiazoles and 2-(alkylthio)-1,3-benzothiazoles.

Yang Y, Qiu F, Josephs JL, Humphreys WG, Shu YZ. Yang Y, et al. Among authors: humphreys wg. Chem Res Toxicol. 2012 Dec 17;25(12):2770-9. doi: 10.1021/tx3003998. Epub 2012 Nov 30. Chem Res Toxicol. 2012. PMID: 23148672

2

Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery.

Fura A, Shu YZ, Zhu M, Hanson RL, Roongta V, Humphreys WG. Fura A, et al. Among authors: humphreys wg. J Med Chem. 2004 Aug 26;47(18):4339-51. doi: 10.1021/jm040066v. J Med Chem. 2004. PMID: 15317447 Review. No abstract available.

3

Dansyl glutathione as a trapping agent for the quantitative estimation and identification of reactive metabolites.

Gan J, Harper TW, Hsueh MM, Qu Q, Humphreys WG. Gan J, et al. Among authors: humphreys wg. Chem Res Toxicol. 2005 May;18(5):896-903. doi: 10.1021/tx0496791. Chem Res Toxicol. 2005. PMID: 15892584

4

Safety assessment of drug metabolites: Characterization of chemically stable metabolites.

Humphreys WG, Unger SE. Humphreys WG, et al. Chem Res Toxicol. 2006 Dec;19(12):1564-9. doi: 10.1021/tx6002547. Chem Res Toxicol. 2006. PMID: 17173369

5

Screening and identification of GSH-trapped reactive metabolites using hybrid triple quadruple linear ion trap mass spectrometry.

Zheng J, Ma L, Xin B, Olah T, Humphreys WG, Zhu M. Zheng J, et al. Among authors: humphreys wg. Chem Res Toxicol. 2007 May;20(5):757-66. doi: 10.1021/tx600277y. Epub 2007 Apr 3. Chem Res Toxicol. 2007. PMID: 17402749

6

Metabolite generation via microbial biotransformations with Actinomycetes: rapid screening for active strains and biosynthesis of important human metabolites of two development-stage compounds, 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101) and dasatinib.

Li W, Josephs JL, Skiles GL, Humphreys WG. Li W, et al. Among authors: humphreys wg. Drug Metab Dispos. 2008 Apr;36(4):721-30. doi: 10.1124/dmd.107.019570. Epub 2008 Jan 28. Drug Metab Dispos. 2008. PMID: 18227141

7

In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation.

Gan J, Ruan Q, He B, Zhu M, Shyu WC, Humphreys WG. Gan J, et al. Among authors: humphreys wg. Chem Res Toxicol. 2009 Apr;22(4):690-8. doi: 10.1021/tx800368n. Chem Res Toxicol. 2009. PMID: 19253935

8

Algorithm for thorough background subtraction of high-resolution LC/MS data: application to obtain clean product ion spectra from nonselective collision-induced dissociation experiments.

Zhang H, Grubb M, Wu W, Josephs J, Humphreys WG. Zhang H, et al. Among authors: humphreys wg. Anal Chem. 2009 Apr 1;81(7):2695-700. doi: 10.1021/ac8027189. Anal Chem. 2009. PMID: 19254033

9

Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.

Zhuo X, Zhao W, Zheng J, Humphreys WG, Shu YZ, Zhu M. Zhuo X, et al. Among authors: humphreys wg. Chem Biol Interact. 2009 Oct 7;181(2):227-35. doi: 10.1016/j.cbi.2009.06.017. Epub 2009 Jul 2. Chem Biol Interact. 2009. PMID: 19576871

10

The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract.

D'Agostino J, Zhuo X, Shadid M, Morgan DG, Zhang X, Humphreys WG, Shu YZ, Yost GS, Ding X. D'Agostino J, et al. Among authors: humphreys wg. Drug Metab Dispos. 2009 Oct;37(10):2018-27. doi: 10.1124/dmd.109.027300. Epub 2009 Jul 16. Drug Metab Dispos. 2009. PMID: 19608696 Free PMC article.

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