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B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice.
Hwang SH, Lee H, Yamamoto M, Jones LA, Dayalan J, Hopkins R, Zhou XJ, Yarovinsky F, Connolly JE, Curotto de Lafaille MA, Wakeland EK, Fairhurst AM. Hwang SH, et al. Among authors: fairhurst am. J Immunol. 2012 Dec 15;189(12):5786-96. doi: 10.4049/jimmunol.1202195. Epub 2012 Nov 12. J Immunol. 2012. PMID: 23150717 Free PMC article.
Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice.
Fairhurst AM, Mathian A, Connolly JE, Wang A, Gray HF, George TA, Boudreaux CD, Zhou XJ, Li QZ, Koutouzov S, Banchereau J, Wakeland EK. Fairhurst AM, et al. Eur J Immunol. 2008 Jul;38(7):1948-60. doi: 10.1002/eji.200837925. Eur J Immunol. 2008. PMID: 18506882 Free PMC article.
Yaa autoimmune phenotypes are conferred by overexpression of TLR7.
Fairhurst AM, Hwang SH, Wang A, Tian XH, Boudreaux C, Zhou XJ, Casco J, Li QZ, Connolly JE, Wakeland EK. Fairhurst AM, et al. Eur J Immunol. 2008 Jul;38(7):1971-8. doi: 10.1002/eji.200838138. Eur J Immunol. 2008. PMID: 18521959 Free PMC article.
CXCR4/CXCL12 hyperexpression plays a pivotal role in the pathogenesis of lupus.
Wang A, Fairhurst AM, Tus K, Subramanian S, Liu Y, Lin F, Igarashi P, Zhou XJ, Batteux F, Wong D, Wakeland EK, Mohan C. Wang A, et al. Among authors: fairhurst am. J Immunol. 2009 Apr 1;182(7):4448-58. doi: 10.4049/jimmunol.0801920. J Immunol. 2009. PMID: 19299746 Free PMC article.
53 results