Bomke J - Search Results

1

Structural and biophysical characterization of the Syk activation switch.

Grädler U, Schwarz D, Dresing V, Musil D, Bomke J, Frech M, Greiner H, Jäkel S, Rysiok T, Müller-Pompalla D, Wegener A. Grädler U, et al. Among authors: bomke j. J Mol Biol. 2013 Jan 23;425(2):309-33. doi: 10.1016/j.jmb.2012.11.007. Epub 2012 Nov 12. J Mol Biol. 2013. PMID: 23154170

2

Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process.

Leykauf K, Salek M, Bomke J, Frech M, Lehmann WD, Dürst M, Alonso A. Leykauf K, et al. Among authors: bomke j. J Cell Sci. 2006 Sep 1;119(Pt 17):3634-42. doi: 10.1242/jcs.03149. J Cell Sci. 2006. PMID: 16931598

3

Structure of the leech protein saratin and characterization of its binding to collagen.

Gronwald W, Bomke J, Maurer T, Domogalla B, Huber F, Schumann F, Kremer W, Fink F, Rysiok T, Frech M, Kalbitzer HR. Gronwald W, et al. Among authors: bomke j. J Mol Biol. 2008 Sep 12;381(4):913-27. doi: 10.1016/j.jmb.2008.06.034. Epub 2008 Jun 18. J Mol Biol. 2008. PMID: 18585393

4

Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex.

Stefer S, Reitz S, Wang F, Wild K, Pang YY, Schwarz D, Bomke J, Hein C, Löhr F, Bernhard F, Denic V, Dötsch V, Sinning I. Stefer S, et al. Among authors: bomke j. Science. 2011 Aug 5;333(6043):758-62. doi: 10.1126/science.1207125. Epub 2011 Jun 30. Science. 2011. PMID: 21719644 Free PMC article.

5

Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.

Buchstaller HP, Eggenweiler HM, Sirrenberg C, Grädler U, Musil D, Hoppe E, Zimmermann A, Schwartz H, März J, Bomke J, Wegener A, Wolf M. Buchstaller HP, et al. Among authors: bomke j. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4396-403. doi: 10.1016/j.bmcl.2012.04.121. Epub 2012 May 5. Bioorg Med Chem Lett. 2012. PMID: 22632933

6

Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors.

Heinrich T, Seenisamy J, Emmanuvel L, Kulkarni SS, Bomke J, Rohdich F, Greiner H, Esdar C, Krier M, Grädler U, Musil D. Heinrich T, et al. Among authors: bomke j. J Med Chem. 2013 Feb 14;56(3):1160-70. doi: 10.1021/jm3016014. Epub 2013 Jan 22. J Med Chem. 2013. PMID: 23294348

7

Fragment-based discovery of focal adhesion kinase inhibitors.

Grädler U, Bomke J, Musil D, Dresing V, Lehmann M, Hölzemann G, Greiner H, Esdar C, Krier M, Heinrich T. Grädler U, et al. Among authors: bomke j. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5401-9. doi: 10.1016/j.bmcl.2013.07.050. Epub 2013 Jul 31. Bioorg Med Chem Lett. 2013. PMID: 23973211

8

Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies.

Gaspari R, Rechlin C, Heine A, Bottegoni G, Rocchia W, Schwarz D, Bomke J, Gerber HD, Klebe G, Cavalli A. Gaspari R, et al. Among authors: bomke j. J Med Chem. 2016 May 12;59(9):4245-56. doi: 10.1021/acs.jmedchem.5b01643. Epub 2016 Jan 12. J Med Chem. 2016. PMID: 26700575

9

Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates.

Heinrich T, Buchstaller HP, Cezanne B, Rohdich F, Bomke J, Friese-Hamim M, Krier M, Knöchel T, Musil D, Leuthner B, Zenke F. Heinrich T, et al. Among authors: bomke j. Bioorg Med Chem Lett. 2017 Feb 1;27(3):551-556. doi: 10.1016/j.bmcl.2016.12.019. Epub 2016 Dec 8. Bioorg Med Chem Lett. 2017. PMID: 27998678

10

Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors.

Heinrich T, Seenisamy J, Blume B, Bomke J, Calderini M, Eckert U, Friese-Hamim M, Kohl R, Lehmann M, Leuthner B, Musil D, Rohdich F, Zenke FT. Heinrich T, et al. Among authors: bomke j. J Med Chem. 2019 May 23;62(10):5025-5039. doi: 10.1021/acs.jmedchem.9b00041. Epub 2019 May 2. J Med Chem. 2019. PMID: 30939017

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