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11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.
Luo MJ, Thieringer R, Springer MS, Wright SD, Hermanowski-Vosatka A, Plump A, Balkovec JM, Cheng K, Ding GJ, Kawka DW, Koo GC, Grand CB, Luo Q, Maletic MM, Malkowitz L, Shah K, Singer I, Waddell ST, Wu KK, Yuan J, Zhu J, Stepaniants S, Yang X, Lum PY, Wang IM. Luo MJ, et al. Among authors: stepaniants s. Physiol Genomics. 2013 Jan 7;45(1):47-57. doi: 10.1152/physiolgenomics.00109.2012. Epub 2012 Nov 20. Physiol Genomics. 2013. PMID: 23170035
Identification and validation of genes affecting aortic lesions in mice.
Yang X, Peterson L, Thieringer R, Deignan JL, Wang X, Zhu J, Wang S, Zhong H, Stepaniants S, Beaulaurier J, Wang IM, Rosa R, Cumiskey AM, Luo JM, Luo Q, Shah K, Xiao J, Nickle D, Plump A, Schadt EE, Lusis AJ, Lum PY. Yang X, et al. Among authors: stepaniants s. J Clin Invest. 2010 Jul;120(7):2414-22. doi: 10.1172/JCI42742. Epub 2010 Jun 23. J Clin Invest. 2010. PMID: 20577049 Free PMC article.
Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers.
Wang IM, Zhang B, Yang X, Zhu J, Stepaniants S, Zhang C, Meng Q, Peters M, He Y, Ni C, Slipetz D, Crackower MA, Houshyar H, Tan CM, Asante-Appiah E, O'Neill G, Luo MJ, Thieringer R, Yuan J, Chiu CS, Lum PY, Lamb J, Boie Y, Wilkinson HA, Schadt EE, Dai H, Roberts C. Wang IM, et al. Among authors: stepaniants s. Mol Syst Biol. 2012 Jul 17;8:594. doi: 10.1038/msb.2012.24. Mol Syst Biol. 2012. PMID: 22806142 Free PMC article.
Integrated genomic and proteomic analyses of gene expression in Mammalian cells.
Tian Q, Stepaniants SB, Mao M, Weng L, Feetham MC, Doyle MJ, Yi EC, Dai H, Thorsson V, Eng J, Goodlett D, Berger JP, Gunter B, Linseley PS, Stoughton RB, Aebersold R, Collins SJ, Hanlon WA, Hood LE. Tian Q, et al. Among authors: stepaniants sb. Mol Cell Proteomics. 2004 Oct;3(10):960-9. doi: 10.1074/mcp.M400055-MCP200. Epub 2004 Jul 6. Mol Cell Proteomics. 2004. PMID: 15238602 Free article.
Genes related to emphysema are enriched for ubiquitination pathways.
Stepaniants S, Wang IM, Boie Y, Mortimer J, Kennedy B, Elliott M, Hayashi S, Luo H, Wong J, Loy L, Coulter S, Roberts CJ, Hogg JC, Sin DD, O'Neill G, Crackower M, Morris M, Paré PD, Obeidat M. Stepaniants S, et al. BMC Pulm Med. 2014 Nov 29;14:187. doi: 10.1186/1471-2466-14-187. BMC Pulm Med. 2014. PMID: 25432663 Free PMC article.
Biomarkers of the Hedgehog/Smoothened pathway in healthy volunteers.
Kadam SK, Patel BK, Jones E, Nguyen TS, Verma LK, Landschulz KT, Stepaniants S, Li B, Brandt JT, Brail LH. Kadam SK, et al. Among authors: stepaniants s. Am J Transl Res. 2012;4(2):229-39. Epub 2012 Apr 18. Am J Transl Res. 2012. PMID: 22611475 Free PMC article.
A gene expression signature that classifies human atherosclerotic plaque by relative inflammation status.
Puig O, Yuan J, Stepaniants S, Zieba R, Zycband E, Morris M, Coulter S, Yu X, Menke J, Woods J, Chen F, Ramey DR, He X, O'Neill EA, Hailman E, Johns DG, Hubbard BK, Yee Lum P, Wright SD, Desouza MM, Plump A, Reiser V. Puig O, et al. Among authors: stepaniants s. Circ Cardiovasc Genet. 2011 Dec;4(6):595-604. doi: 10.1161/CIRCGENETICS.111.960773. Epub 2011 Oct 18. Circ Cardiovasc Genet. 2011. PMID: 22010137
Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer.
Wang IM, Stepaniants S, Boie Y, Mortimer JR, Kennedy B, Elliott M, Hayashi S, Loy L, Coulter S, Cervino S, Harris J, Thornton M, Raubertas R, Roberts C, Hogg JC, Crackower M, O'Neill G, Paré PD. Wang IM, et al. Among authors: stepaniants s. Am J Respir Crit Care Med. 2008 Feb 15;177(4):402-11. doi: 10.1164/rccm.200703-390OC. Epub 2007 Nov 1. Am J Respir Crit Care Med. 2008. PMID: 17975202
25 results