Klein MT - Search Results

1

Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.

Tarr JC, Turlington ML, Reid PR, Utley TJ, Sheffler DJ, Cho HP, Klar R, Pancani T, Klein MT, Bridges TM, Morrison RD, Blobaum AL, Xiang Z, Daniels JS, Niswender CM, Conn PJ, Wood MR, Lindsley CW. Tarr JC, et al. Among authors: klein mt. ACS Chem Neurosci. 2012 Nov 21;3(11):884-95. doi: 10.1021/cn300068s. Epub 2012 Jul 18. ACS Chem Neurosci. 2012. PMID: 23173069 Free PMC article.

2

Approaches for probing allosteric interactions at 7 transmembrane spanning receptors.

Klein MT, Vinson PN, Niswender CM. Klein MT, et al. Prog Mol Biol Transl Sci. 2013;115:1-59. doi: 10.1016/B978-0-12-394587-7.00001-4. Prog Mol Biol Transl Sci. 2013. PMID: 23415091 Free PMC article. Review.

3

The effect of prototypic sigma ligands on the binding of [3H]dextromethorphan to guinea pig brain.

Klein M, Paturzo JJ, Musacchio JM. Klein M, et al. Neurosci Lett. 1989 Feb 13;97(1-2):175-80. doi: 10.1016/0304-3940(89)90159-6. Neurosci Lett. 1989. PMID: 2537477 Free article.

4

Effects of dextromethorphan site ligands and allosteric modifiers on the binding of (+)-[3H]3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine.

Musacchio JM, Klein M, Paturzo JJ. Musacchio JM, et al. Mol Pharmacol. 1989 Jan;35(1):1-5. Mol Pharmacol. 1989. PMID: 2536463

5

Computer-assisted analysis of dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine binding sites in rat brain. Allosteric effects of ropizine.

Klein M, Musacchio JM. Klein M, et al. Life Sci. 1990;47(18):1625-34. doi: 10.1016/0024-3205(90)90367-z. Life Sci. 1990. PMID: 2250576

6

High affinity dextromethorphan binding sites in guinea pig brain: further characterization and allosteric interactions.

Musacchio JM, Klein M, Santiago LJ. Musacchio JM, et al. J Pharmacol Exp Ther. 1988 Nov;247(2):424-31. J Pharmacol Exp Ther. 1988. PMID: 3183944

7

High-affinity dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine binding sites in rat brain. Allosteric effects of ropizine.

Klein M, Musacchio JM. Klein M, et al. J Pharmacol Exp Ther. 1992 Mar;260(3):990-9. J Pharmacol Exp Ther. 1992. PMID: 1312173

8

Dextromethorphan and sigma ligands: common sites but diverse effects.

Musacchio JM, Klein M, Canoll PD. Musacchio JM, et al. Life Sci. 1989;45(19):1721-32. doi: 10.1016/0024-3205(89)90510-9. Life Sci. 1989. PMID: 2556614 Free article. Review.

9

Effects of haloperidol and reduced haloperidol on binding to sigma sites.

Klein M, Cooper TB, Musacchio JM. Klein M, et al. Eur J Pharmacol. 1994 Mar 21;254(3):239-48. doi: 10.1016/0014-2999(94)90460-x. Eur J Pharmacol. 1994. PMID: 8013558

10

Allosteric modulation of dextromethorphan binding sites.

Musacchio JM, Klein M, Santiago LJ. Musacchio JM, et al. Neuropharmacology. 1987 Jul;26(7B):997-1001. doi: 10.1016/0028-3908(87)90078-5. Neuropharmacology. 1987. PMID: 2821439 Review.

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