Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

57 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Publication Date timeline is not available.
Page 1
Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.
Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Miyata Y, et al. Among authors: jinwal uk. ACS Chem Neurosci. 2013 Jun 19;4(6):930-9. doi: 10.1021/cn300210g. Epub 2013 Mar 20. ACS Chem Neurosci. 2013. PMID: 23472668 Free PMC article.
Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.
Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM Jr, Zuiderweg ER, Gestwicki JE, Dickey CA. Fontaine SN, et al. Among authors: jinwal uk. J Biol Chem. 2015 May 22;290(21):13115-27. doi: 10.1074/jbc.M115.637595. Epub 2015 Apr 11. J Biol Chem. 2015. PMID: 25864199 Free PMC article.
Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy.
Young ZT, Rauch JN, Assimon VA, Jinwal UK, Ahn M, Li X, Dunyak BM, Ahmad A, Carlson GA, Srinivasan SR, Zuiderweg ER, Dickey CA, Gestwicki JE. Young ZT, et al. Among authors: jinwal uk. Cell Chem Biol. 2016 Aug 18;23(8):992-1001. doi: 10.1016/j.chembiol.2016.04.014. Epub 2016 Aug 4. Cell Chem Biol. 2016. PMID: 27499529 Free PMC article.
Facilitating Akt clearance via manipulation of Hsp70 activity and levels.
Koren J 3rd, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA. Koren J 3rd, et al. Among authors: jinwal uk. J Biol Chem. 2010 Jan 22;285(4):2498-505. doi: 10.1074/jbc.M109.057208. Epub 2009 Nov 4. J Biol Chem. 2010. PMID: 19889640 Free PMC article.
Hsc70 rapidly engages tau after microtubule destabilization.
Jinwal UK, O'Leary JC 3rd, Borysov SI, Jones JR, Li Q, Koren J 3rd, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA. Jinwal UK, et al. J Biol Chem. 2010 May 28;285(22):16798-805. doi: 10.1074/jbc.M110.113753. Epub 2010 Mar 22. J Biol Chem. 2010. PMID: 20308058 Free PMC article.
Identification of dihydropyridines that reduce cellular tau levels.
Evans CG, Jinwal UK, Makley LN, Dickey CA, Gestwicki JE. Evans CG, et al. Among authors: jinwal uk. Chem Commun (Camb). 2011 Jan 7;47(1):529-31. doi: 10.1039/c0cc02253e. Epub 2010 Nov 16. Chem Commun (Camb). 2011. PMID: 21082080 Free PMC article.
DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.
Abisambra JF, Jinwal UK, Suntharalingam A, Arulselvam K, Brady S, Cockman M, Jin Y, Zhang B, Dickey CA. Abisambra JF, et al. Among authors: jinwal uk. J Mol Biol. 2012 Aug 24;421(4-5):653-61. doi: 10.1016/j.jmb.2012.02.003. Epub 2012 Feb 15. J Mol Biol. 2012. PMID: 22343013 Free PMC article.
57 results