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Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Hebert AS, et al. Among authors: yu w. Mol Cell. 2013 Jan 10;49(1):186-99. doi: 10.1016/j.molcel.2012.10.024. Epub 2012 Nov 29. Mol Cell. 2013. PMID: 23201123 Free PMC article.
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction.
Hallows WC, Yu W, Smith BC, Devries MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM. Hallows WC, et al. Among authors: yu w. Mol Cell. 2011 Jan 21;41(2):139-49. doi: 10.1016/j.molcel.2011.01.002. Mol Cell. 2011. PMID: 21255725 Free PMC article.
Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies.
Yu W, Denu RA, Krautkramer KA, Grindle KM, Yang DT, Asimakopoulos F, Hematti P, Denu JM. Yu W, et al. J Biol Chem. 2016 Feb 12;291(7):3268-79. doi: 10.1074/jbc.M115.702076. Epub 2015 Dec 2. J Biol Chem. 2016. PMID: 26631723 Free PMC article.
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice.
Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, Chandel NS, Denu JM, Mrksich M, Bass J. Peek CB, et al. Among authors: yu w. Science. 2013 Nov 1;342(6158):1243417. doi: 10.1126/science.1243417. Epub 2013 Sep 19. Science. 2013. PMID: 24051248 Free PMC article.
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