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The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.
Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, Fergusson MM, Liu J, Rovira II, Cheng HL, Wang G, Gucek M, Lombard D, Alt FW, Sack MN, Murphy E, Cao L, Finkel T. Narayan N, et al. Nature. 2012 Dec 13;492(7428):199-204. doi: 10.1038/nature11700. Epub 2012 Nov 28. Nature. 2012. Retraction in: Nature. 2014 Feb 27;506(7489):516. doi: 10.1038/nature12897 PMID: 23201684 Retracted.
Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.
Wu JJ, Liu J, Chen EB, Wang JJ, Cao L, Narayan N, Fergusson MM, Rovira II, Allen M, Springer DA, Lago CU, Zhang S, DuBois W, Ward T, deCabo R, Gavrilova O, Mock B, Finkel T. Wu JJ, et al. Among authors: narayan n. Cell Rep. 2013 Sep 12;4(5):913-20. doi: 10.1016/j.celrep.2013.07.030. Epub 2013 Aug 29. Cell Rep. 2013. PMID: 23994476 Free PMC article.
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
Yun H, Narayan N, Vohra S, Giotopoulos G, Mupo A, Madrigal P, Sasca D, Lara-Astiaso D, Horton SJ, Agrawal-Singh S, Meduri E, Basheer F, Marando L, Gozdecka M, Dovey OM, Castillo-Venzor A, Wang X, Gallipoli P, Müller-Tidow C, Osborne CS, Vassiliou GS, Huntly BJP. Yun H, et al. Among authors: narayan n. Nat Genet. 2021 Oct;53(10):1443-1455. doi: 10.1038/s41588-021-00925-9. Epub 2021 Sep 23. Nat Genet. 2021. PMID: 34556857 Free PMC article.
Letting the breaks off MYCN.
Perini G, Milazzo G, Narayan N, Ekert PG. Perini G, et al. Among authors: narayan n. Cell Death Differ. 2016 Dec;23(12):1904-1905. doi: 10.1038/cdd.2016.112. Epub 2016 Oct 14. Cell Death Differ. 2016. PMID: 27740622 Free PMC article. No abstract available.
In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis.
Lara-Astiaso D, Goñi-Salaverri A, Mendieta-Esteban J, Narayan N, Del Valle C, Gross T, Giotopoulos G, Beinortas T, Navarro-Alonso M, Aguado-Alvaro LP, Zazpe J, Marchese F, Torrea N, Calvo IA, Lopez CK, Alignani D, Lopez A, Saez B, Taylor-King JP, Prosper F, Fortelny N, Huntly BJP. Lara-Astiaso D, et al. Among authors: narayan n. Nat Genet. 2023 Sep;55(9):1542-1554. doi: 10.1038/s41588-023-01471-2. Epub 2023 Aug 14. Nat Genet. 2023. PMID: 37580596 Free PMC article.
Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice.
Gangoda L, Doerflinger M, Srivastava R, Narayan N, Edgington LE, Orian J, Hawkins C, O'Reilly LA, Gu H, Bogyo M, Ekert P, Strasser A, Puthalakath H. Gangoda L, et al. Among authors: narayan n. Cell Death Differ. 2014 Nov;21(11):1815-24. doi: 10.1038/cdd.2014.98. Epub 2014 Jul 11. Cell Death Differ. 2014. PMID: 25012505 Free PMC article.
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