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AAV6-βARKct gene delivery mediated by molecular cardiac surgery with recirculating delivery (MCARD) in sheep results in robust gene expression and increased adrenergic reserve.
Katz MG, Fargnoli AS, Swain JD, Tomasulo CE, Ciccarelli M, Huang ZM, Rabinowitz JE, Bridges CR. Katz MG, et al. Among authors: rabinowitz je. J Thorac Cardiovasc Surg. 2012 Mar;143(3):720-726.e3. doi: 10.1016/j.jtcvs.2011.08.048. Epub 2011 Dec 3. J Thorac Cardiovasc Surg. 2012. PMID: 22143102 Free PMC article.
The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition.
Völkers M, Weidenhammer C, Herzog N, Qiu G, Spaich K, Wegner FV, Peppel K, Müller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, Friedrich O, Most P. Völkers M, et al. Among authors: rabinowitz je. Circ Res. 2011 Jan 7;108(1):27-39. doi: 10.1161/CIRCRESAHA.110.225201. Epub 2010 Nov 24. Circ Res. 2011. PMID: 21106943 Free PMC article.
β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy.
Cannavo A, Rengo G, Liccardo D, Pagano G, Zincarelli C, De Angelis MC, Puglia R, Di Pietro E, Rabinowitz JE, Barone MV, Cirillo P, Trimarco B, Palmer TM, Ferrara N, Koch WJ, Leosco D, Rapacciuolo A. Cannavo A, et al. Among authors: rabinowitz je. Circulation. 2013 Oct 8;128(15):1612-22. doi: 10.1161/CIRCULATIONAHA.113.002659. Epub 2013 Aug 22. Circulation. 2013. PMID: 23969695 Free PMC article.
43 results