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A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies.
Bengtsson A, Joergensen L, Rask TS, Olsen RW, Andersen MA, Turner L, Theander TG, Hviid L, Higgins MK, Craig A, Brown A, Jensen AT. Bengtsson A, et al. Among authors: higgins mk. J Immunol. 2013 Jan 1;190(1):240-9. doi: 10.4049/jimmunol.1202578. Epub 2012 Dec 3. J Immunol. 2013. PMID: 23209327 Free PMC article.
Carbohydrate binding molecules in malaria pathology.
Brown A, Higgins MK. Brown A, et al. Among authors: higgins mk. Curr Opin Struct Biol. 2010 Oct;20(5):560-6. doi: 10.1016/j.sbi.2010.06.008. Epub 2010 Jul 23. Curr Opin Struct Biol. 2010. PMID: 20655195 Review.
Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants.
Barfod L, Dobrilovic T, Magistrado P, Khunrae P, Viwami F, Bruun J, Dahlbäck M, Bernasconi NL, Fried M, John D, Duffy PE, Salanti A, Lanzavecchia A, Lim CT, Ndam NT, Higgins MK, Hviid L. Barfod L, et al. Among authors: higgins mk. J Immunol. 2010 Dec 15;185(12):7553-61. doi: 10.4049/jimmunol.1002390. Epub 2010 Nov 15. J Immunol. 2010. PMID: 21078904 Free PMC article.
Severe malaria is associated with parasite binding to endothelial protein C receptor.
Turner L, Lavstsen T, Berger SS, Wang CW, Petersen JE, Avril M, Brazier AJ, Freeth J, Jespersen JS, Nielsen MA, Magistrado P, Lusingu J, Smith JD, Higgins MK, Theander TG. Turner L, et al. Among authors: higgins mk. Nature. 2013 Jun 27;498(7455):502-5. doi: 10.1038/nature12216. Epub 2013 Jun 5. Nature. 2013. PMID: 23739325 Free PMC article.
Rosetting Plasmodium falciparum-infected erythrocytes bind to human brain microvascular endothelial cells in vitro, demonstrating a dual adhesion phenotype mediated by distinct P. falciparum erythrocyte membrane protein 1 domains.
Adams Y, Kuhnrae P, Higgins MK, Ghumra A, Rowe JA. Adams Y, et al. Among authors: higgins mk. Infect Immun. 2014 Mar;82(3):949-59. doi: 10.1128/IAI.01233-13. Epub 2013 Dec 16. Infect Immun. 2014. PMID: 24343658 Free PMC article.
148 results