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Novel competitive irreversible inhibitors of aldehyde dehydrogenase (ALDH1): restoration of chemosensitivity of L1210 cells overexpressing ALDH1 and induction of apoptosis in BAF(3) cells overexpressing bcl(2).
Quash G, Fournet G, Chantepie J, Gore J, Ardiet C, Ardail D, Michal Y, Reichert U. Quash G, et al. Among authors: fournet g. Biochem Pharmacol. 2002 Oct 15;64(8):1279-92. doi: 10.1016/s0006-2952(02)01294-7. Biochem Pharmacol. 2002. PMID: 12234608
Aldehyde dehydrogenase inhibitors: alpha,beta-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture.
Quash G, Fournet G, Courvoisier C, Martinez RM, Chantepie J, Paret MJ, Pharaboz J, Joly-Pharaboz MO, Goré J, André J, Reichert U. Quash G, et al. Among authors: fournet g. Eur J Med Chem. 2008 May;43(5):906-16. doi: 10.1016/j.ejmech.2007.06.004. Epub 2007 Jul 6. Eur J Med Chem. 2008. PMID: 17692435
The pharmacomodulation of the N atom of alpha,beta-acetylenic aminothiolesters or the replacement of the thiolester moiety by more electrophilic groups did not permit any clear rationale to be established for improving the selective growth-inhibitory activity of this family of co …
The pharmacomodulation of the N atom of alpha,beta-acetylenic aminothiolesters or the replacement of the thiolester moiety by more electroph …
45 results