Roth BL - Search Results

1

Automated design of ligands to polypharmacological profiles.

Besnard J, Ruda GF, Setola V, Abecassis K, Rodriguiz RM, Huang XP, Norval S, Sassano MF, Shin AI, Webster LA, Simeons FR, Stojanovski L, Prat A, Seidah NG, Constam DB, Bickerton GR, Read KD, Wetsel WC, Gilbert IH, Roth BL, Hopkins AL. Besnard J, et al. Among authors: roth bl. Nature. 2012 Dec 13;492(7428):215-20. doi: 10.1038/nature11691. Nature. 2012. PMID: 23235874 Free PMC article.

2

Why mice are neither miniature humans nor small rats: a cautionary tale involving 5-hydroxytryptamine-6 serotonin receptor species variants.

Setola V, Roth BL. Setola V, et al. Among authors: roth bl. Mol Pharmacol. 2003 Dec;64(6):1277-8. doi: 10.1124/mol.64.6.1277. Mol Pharmacol. 2003. PMID: 14645656 Review. No abstract available.

3

1,2,3,4-tetrahydrocarbazoles as 5-HT6 serotonin receptor ligands.

Chang-Fong J, Rangisetty JB, Dukat M, Setola V, Raffay T, Roth B, Glennon RA. Chang-Fong J, et al. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1961-4. doi: 10.1016/j.bmcl.2004.01.071. Bioorg Med Chem Lett. 2004. PMID: 15050637

4

Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'.

Setola V, Roth BL. Setola V, et al. Among authors: roth bl. Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):377-87. doi: 10.1517/17425255.1.3.377. Expert Opin Drug Metab Toxicol. 2005. PMID: 16863450 Review.

5

Relating protein pharmacology by ligand chemistry.

Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Keiser MJ, et al. Among authors: roth bl. Nat Biotechnol. 2007 Feb;25(2):197-206. doi: 10.1038/nbt1284. Nat Biotechnol. 2007. PMID: 17287757

6

N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity.

Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL. Jensen NH, et al. Among authors: roth bl. Neuropsychopharmacology. 2008 Sep;33(10):2303-12. doi: 10.1038/sj.npp.1301646. Epub 2007 Dec 5. Neuropsychopharmacology. 2008. PMID: 18059438

7

Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil.

Zolkowska D, Jain R, Rothman RB, Partilla JS, Roth BL, Setola V, Prisinzano TE, Baumann MH. Zolkowska D, et al. Among authors: roth bl. J Pharmacol Exp Ther. 2009 May;329(2):738-46. doi: 10.1124/jpet.108.146142. Epub 2009 Feb 5. J Pharmacol Exp Ther. 2009. PMID: 19197004 Free PMC article.

8

Predicting new molecular targets for known drugs.

Keiser MJ, Setola V, Irwin JJ, Laggner C, Abbas AI, Hufeisen SJ, Jensen NH, Kuijer MB, Matos RC, Tran TB, Whaley R, Glennon RA, Hert J, Thomas KL, Edwards DD, Shoichet BK, Roth BL. Keiser MJ, et al. Among authors: roth bl. Nature. 2009 Nov 12;462(7270):175-81. doi: 10.1038/nature08506. Epub 2009 Nov 1. Nature. 2009. PMID: 19881490 Free PMC article.

9

N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B.

Kwon YJ, Saubern S, Macdonald JM, Huang XP, Setola V, Roth BL. Kwon YJ, et al. Among authors: roth bl. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5488-90. doi: 10.1016/j.bmcl.2010.07.074. Epub 2010 Jul 21. Bioorg Med Chem Lett. 2010. PMID: 20692833

10

N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands.

Frankowski KJ, Ghosh P, Setola V, Tran TB, Roth BL, Aubé J. Frankowski KJ, et al. Among authors: roth bl. ACS Med Chem Lett. 2010 Aug 12;1(5):189-193. doi: 10.1021/ml100040t. ACS Med Chem Lett. 2010. PMID: 20729985 Free PMC article.

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