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Page 1
A strategy for modulation of enzymes in the ubiquitin system.
Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, Landry MC, Yeh C, Zeqiraj E, Karamboulas K, Allali-Hassani A, Vedadi M, Tyers M, Moffat J, Sicheri F, Pelletier L, Durocher D, Raught B, Rotin D, Yang J, Moran MF, Dhe-Paganon S, Sidhu SS. Ernst A, et al. Among authors: juang yc. Science. 2013 Feb 1;339(6119):590-5. doi: 10.1126/science.1230161. Epub 2013 Jan 3. Science. 2013. PMID: 23287719 Free PMC article.
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.
Juang YC, Landry MC, Sanches M, Vittal V, Leung CC, Ceccarelli DF, Mateo AR, Pruneda JN, Mao DY, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, Durocher D. Juang YC, et al. Mol Cell. 2012 Feb 10;45(3):384-97. doi: 10.1016/j.molcel.2012.01.011. Mol Cell. 2012. PMID: 22325355 Free PMC article.
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Rivkin E, Almeida SM, Ceccarelli DF, Juang YC, MacLean TA, Srikumar T, Huang H, Dunham WH, Fukumura R, Xie G, Gondo Y, Raught B, Gingras AC, Sicheri F, Cordes SP. Rivkin E, et al. Among authors: juang yc. Nature. 2013 Jun 20;498(7454):318-24. doi: 10.1038/nature12296. Epub 2013 May 24. Nature. 2013. PMID: 23708998 Free PMC article.
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.
Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D. Canny MD, et al. Among authors: juang yc. Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27. Nat Biotechnol. 2018. PMID: 29176614 Free PMC article.
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D. Nakada S, et al. Among authors: juang yc. Nature. 2010 Aug 19;466(7309):941-6. doi: 10.1038/nature09297. Nature. 2010. PMID: 20725033
Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Huang H, Zeqiraj E, Dong B, Jha BK, Duffy NM, Orlicky S, Thevakumaran N, Talukdar M, Pillon MC, Ceccarelli DF, Wan LC, Juang YC, Mao DY, Gaughan C, Brinton MA, Perelygin AA, Kourinov I, Guarné A, Silverman RH, Sicheri F. Huang H, et al. Among authors: juang yc. Mol Cell. 2014 Jan 23;53(2):221-34. doi: 10.1016/j.molcel.2013.12.025. Mol Cell. 2014. PMID: 24462203 Free PMC article.
Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK.
Taylor CA 4th, Juang YC, Earnest S, Sengupta S, Goldsmith EJ, Cobb MH. Taylor CA 4th, et al. Among authors: juang yc. Biochemistry. 2015 Aug 18;54(32):5063-71. doi: 10.1021/acs.biochem.5b00593. Epub 2015 Aug 3. Biochemistry. 2015. PMID: 26208601 Free PMC article.
WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.
Anselmo AN, Earnest S, Chen W, Juang YC, Kim SC, Zhao Y, Cobb MH. Anselmo AN, et al. Among authors: juang yc. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10883-8. doi: 10.1073/pnas.0604607103. Epub 2006 Jul 10. Proc Natl Acad Sci U S A. 2006. PMID: 16832045 Free PMC article.
Characterization of mitogen-activated protein kinase (MAPK) dimers.
Wilsbacher JL, Juang YC, Khokhlatchev AV, Gallagher E, Binns D, Goldsmith EJ, Cobb MH. Wilsbacher JL, et al. Among authors: juang yc. Biochemistry. 2006 Nov 7;45(44):13175-82. doi: 10.1021/bi061041w. Biochemistry. 2006. PMID: 17073439
42 results