Harran P - Search Results

1

Small-molecule activation of the TRAIL receptor DR5 in human cancer cells.

Wang G, Wang X, Yu H, Wei S, Williams N, Holmes DL, Halfmann R, Naidoo J, Wang L, Li L, Chen S, Harran P, Lei X, Wang X. Wang G, et al. Among authors: harran p. Nat Chem Biol. 2013 Feb;9(2):84-9. doi: 10.1038/nchembio.1153. Epub 2012 Dec 23. Nat Chem Biol. 2013. PMID: 23292651

2

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.

Wender PA, DeBrabander J, Harran PG, Jimenez JM, Koehler MF, Lippa B, Park CM, Siedenbiedel C, Pettit GR. Wender PA, et al. Among authors: harran pg. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6624-9. doi: 10.1073/pnas.95.12.6624. Proc Natl Acad Sci U S A. 1998. PMID: 9618462 Free PMC article.

3

Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.

Cruz-Monserrate Z, Mullaney JT, Harran PG, Pettit GR, Hamel E. Cruz-Monserrate Z, et al. Eur J Biochem. 2003 Sep;270(18):3822-8. doi: 10.1046/j.1432-1033.2003.03776.x. Eur J Biochem. 2003. PMID: 12950266 Free article.

4

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death.

Li L, Thomas RM, Suzuki H, De Brabander JK, Wang X, Harran PG. Li L, et al. Science. 2004 Sep 3;305(5689):1471-4. doi: 10.1126/science.1098231. Science. 2004. PMID: 15353805

5

Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity.

Williams NS, Burgett AW, Atkins AS, Wang X, Harran PG, McKnight SL. Williams NS, et al. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2074-9. doi: 10.1073/pnas.0611340104. Epub 2007 Feb 7. Proc Natl Acad Sci U S A. 2007. PMID: 17287337 Free PMC article.

6

Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division.

Wang G, Shang L, Burgett AW, Harran PG, Wang X. Wang G, et al. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2068-73. doi: 10.1073/pnas.0610832104. Epub 2007 Feb 7. Proc Natl Acad Sci U S A. 2007. PMID: 17287350 Free PMC article.

7

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis.

Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J, Harran P, Wang X. Petersen SL, et al. Among authors: harran p. Cancer Cell. 2007 Nov;12(5):445-56. doi: 10.1016/j.ccr.2007.08.029. Cancer Cell. 2007. PMID: 17996648 Free PMC article.

8

SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner.

Greer RM, Peyton M, Larsen JE, Girard L, Xie Y, Gazdar AF, Harran P, Wang L, Brekken RA, Wang X, Minna JD. Greer RM, et al. Among authors: harran p. Cancer Res. 2011 Dec 15;71(24):7640-8. doi: 10.1158/0008-5472.CAN-10-3947. Epub 2011 Nov 2. Cancer Res. 2011. PMID: 22049529 Free PMC article.

9

Acid promoted cinnamyl ion mobility within peptide derived macrocycles.

Zhao H, Negash L, Wei Q, LaCour TG, Estill SJ, Capota E, Pieper AA, Harran PG. Zhao H, et al. J Am Chem Soc. 2008 Oct 22;130(42):13864-6. doi: 10.1021/ja803299h. Epub 2008 Sep 24. J Am Chem Soc. 2008. PMID: 18811162

10

A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance.

Zubovych I, Doundoulakis T, Harran PG, Roth MG. Zubovych I, et al. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15523-8. doi: 10.1073/pnas.0607338103. Epub 2006 Oct 10. Proc Natl Acad Sci U S A. 2006. PMID: 17032754 Free PMC article.

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