Seenisamy J - Search Results

1

Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors.

Heinrich T, Seenisamy J, Emmanuvel L, Kulkarni SS, Bomke J, Rohdich F, Greiner H, Esdar C, Krier M, Grädler U, Musil D. Heinrich T, et al. Among authors: seenisamy j. J Med Chem. 2013 Feb 14;56(3):1160-70. doi: 10.1021/jm3016014. Epub 2013 Jan 22. J Med Chem. 2013. PMID: 23294348

2

Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors.

Heinrich T, Seenisamy J, Blume B, Bomke J, Calderini M, Eckert U, Friese-Hamim M, Kohl R, Lehmann M, Leuthner B, Musil D, Rohdich F, Zenke FT. Heinrich T, et al. Among authors: seenisamy j. J Med Chem. 2019 May 23;62(10):5025-5039. doi: 10.1021/acs.jmedchem.9b00041. Epub 2019 May 2. J Med Chem. 2019. PMID: 30939017

3

Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i).

Klein M, Busch M, Friese-Hamim M, Crosignani S, Fuchss T, Musil D, Rohdich F, Sanderson MP, Seenisamy J, Walter-Bausch G, Zanelli U, Hewitt P, Esdar C, Schadt O. Klein M, et al. Among authors: seenisamy j. J Med Chem. 2021 Jul 22;64(14):10230-10245. doi: 10.1021/acs.jmedchem.1c00604. Epub 2021 Jul 6. J Med Chem. 2021. PMID: 34228444

4

Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer.

Heinrich T, Seenisamy J, Becker F, Blume B, Bomke J, Dietz M, Eckert U, Friese-Hamim M, Gunera J, Hansen K, Leuthner B, Musil D, Pfalzgraf J, Rohdich F, Siegl C, Spuck D, Wegener A, Zenke FT. Heinrich T, et al. Among authors: seenisamy j. J Med Chem. 2019 Dec 26;62(24):11119-11134. doi: 10.1021/acs.jmedchem.9b01070. Epub 2019 Dec 3. J Med Chem. 2019. PMID: 31725285

5

Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.

Crosignani S, Prêtre A, Jorand-Lebrun C, Fraboulet G, Seenisamy J, Augustine JK, Missotten M, Humbert Y, Cleva C, Abla N, Daff H, Schott O, Schneider M, Burgat-Charvillon F, Rivron D, Hamernig I, Arrighi JF, Gaudet M, Zimmerli SC, Juillard P, Johnson Z. Crosignani S, et al. Among authors: seenisamy j. J Med Chem. 2011 Oct 27;54(20):7299-317. doi: 10.1021/jm200866y. Epub 2011 Oct 3. J Med Chem. 2011. PMID: 21916510

6

Synthesis and SAR development of quinoline analogs as novel P2X7 receptor antagonists.

Xiao Y, Karra S, Goutopoulos A, Morse NT, Zhang S, Dhanabal M, Tian H, Seenisamy J, Jayadevan J, Caldwell R, Potnick J, Bleich M, Chekler E, Sherer B, Sriraman V. Xiao Y, et al. Among authors: seenisamy j. Bioorg Med Chem Lett. 2019 Jul 1;29(13):1660-1664. doi: 10.1016/j.bmcl.2019.04.033. Epub 2019 Apr 24. Bioorg Med Chem Lett. 2019. PMID: 31031055

7

Solvent-Dependent Photophysics and Reactivity of Monomeric and Dimeric 4-Amino-1,8-Naphthalimides.

Kelly LA, Roll M, Joseph J, Seenisamy J, Barrett J, Kauser K, Warner KS. Kelly LA, et al. Among authors: seenisamy j. J Phys Chem A. 2021 Mar 25;125(11):2294-2307. doi: 10.1021/acs.jpca.0c11639. Epub 2021 Mar 16. J Phys Chem A. 2021. PMID: 33724853

8

Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure.

Rezler EM, Seenisamy J, Bashyam S, Kim MY, White E, Wilson WD, Hurley LH. Rezler EM, et al. Among authors: seenisamy j. J Am Chem Soc. 2005 Jul 6;127(26):9439-47. doi: 10.1021/ja0505088. J Am Chem Soc. 2005. PMID: 15984871

9

Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.

Seenisamy J, Bashyam S, Gokhale V, Vankayalapati H, Sun D, Siddiqui-Jain A, Streiner N, Shin-Ya K, White E, Wilson WD, Hurley LH. Seenisamy J, et al. J Am Chem Soc. 2005 Mar 9;127(9):2944-59. doi: 10.1021/ja0444482. J Am Chem Soc. 2005. PMID: 15740131

10

The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4.

Seenisamy J, Rezler EM, Powell TJ, Tye D, Gokhale V, Joshi CS, Siddiqui-Jain A, Hurley LH. Seenisamy J, et al. J Am Chem Soc. 2004 Jul 21;126(28):8702-9. doi: 10.1021/ja040022b. J Am Chem Soc. 2004. PMID: 15250722

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