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Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.
Hernandez V, Crépin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ. Hernandez V, et al. Among authors: sharma r. Antimicrob Agents Chemother. 2013 Mar;57(3):1394-403. doi: 10.1128/AAC.02058-12. Epub 2013 Jan 7. Antimicrob Agents Chemother. 2013. PMID: 23295920 Free PMC article.
Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.
Freund YR, Akama T, Alley MR, Antunes J, Dong C, Jarnagin K, Kimura R, Nieman JA, Maples KR, Plattner JJ, Rock F, Sharma R, Singh R, Sanders V, Zhou Y. Freund YR, et al. Among authors: sharma r. FEBS Lett. 2012 Sep 21;586(19):3410-4. doi: 10.1016/j.febslet.2012.07.058. Epub 2012 Jul 25. FEBS Lett. 2012. PMID: 22841723 Free article.
Identification and characterization of novel small molecule inhibitors of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU).
Sharma R, Rani C, Mehra R, Nargotra A, Chib R, Rajput VS, Kumar S, Singh S, Sharma PR, Khan IA. Sharma R, et al. Among authors: sharma pr. Appl Microbiol Biotechnol. 2016 Apr;100(7):3071-85. doi: 10.1007/s00253-015-7123-y. Epub 2015 Nov 13. Appl Microbiol Biotechnol. 2016. PMID: 26563552
Synthesis and evaluation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(2-(4-substitutedpiperazin-1-yl)acetyl)piperazin-1-yl)quinoline-3-carboxylic acid derivatives as anti-tubercular and antibacterial agents.
Suresh N, Nagesh HN, Renuka J, Rajput V, Sharma R, Khan IA, Kondapalli Venkata Gowri CS. Suresh N, et al. Among authors: sharma r. Eur J Med Chem. 2014 Jan;71:324-32. doi: 10.1016/j.ejmech.2013.10.055. Epub 2013 Nov 20. Eur J Med Chem. 2014. PMID: 24333580
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