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Page 1
Serum concentrations of A Proliferation-Inducing Ligand (APRIL) are elevated in sepsis and predict mortality in critically ill patients.
Roderburg C, Koch A, Tacke F, Nieuwenhuijsen L, Bruensing J, Vargas Cardenas D, Kreggenwinkel K, Vucur M, Koppe C, Jungebluth P, Seikrit C, Luedde M, Trautwein C, Luedde T. Roderburg C, et al. Among authors: kreggenwinkel k. J Crit Care. 2013 Oct;28(5):882.e1-11. doi: 10.1016/j.jcrc.2012.11.007. Epub 2013 Jan 20. J Crit Care. 2013. PMID: 23337484
RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation.
Vucur M, Reisinger F, Gautheron J, Janssen J, Roderburg C, Cardenas DV, Kreggenwinkel K, Koppe C, Hammerich L, Hakem R, Unger K, Weber A, Gassler N, Luedde M, Frey N, Neumann UP, Tacke F, Trautwein C, Heikenwalder M, Luedde T. Vucur M, et al. Among authors: kreggenwinkel k. Cell Rep. 2013 Aug 29;4(4):776-90. doi: 10.1016/j.celrep.2013.07.035. Epub 2013 Aug 22. Cell Rep. 2013. PMID: 23972991 Free article.
A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis.
Gautheron J, Vucur M, Reisinger F, Cardenas DV, Roderburg C, Koppe C, Kreggenwinkel K, Schneider AT, Bartneck M, Neumann UP, Canbay A, Reeves HL, Luedde M, Tacke F, Trautwein C, Heikenwalder M, Luedde T. Gautheron J, et al. Among authors: kreggenwinkel k. EMBO Mol Med. 2014 Aug;6(8):1062-74. doi: 10.15252/emmm.201403856. EMBO Mol Med. 2014. PMID: 24963148 Free PMC article.
IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.
Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T. Koppe C, et al. Among authors: kreggenwinkel k. Hepatology. 2016 Oct;64(4):1217-31. doi: 10.1002/hep.28723. Epub 2016 Aug 11. Hepatology. 2016. PMID: 27396433
CXCR6 protects from inflammation and fibrosis in NEMOLPC-KO mice.
Liepelt A, Wehr A, Kohlhepp M, Mossanen JC, Kreggenwinkel K, Denecke B, Costa IG, Luedde T, Trautwein C, Tacke F. Liepelt A, et al. Among authors: kreggenwinkel k. Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):391-402. doi: 10.1016/j.bbadis.2018.11.020. Epub 2018 Nov 24. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30476545 Free article.