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Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.
Pollitt AY, Poulter NS, Gitz E, Navarro-Nuñez L, Wang YJ, Hughes CE, Thomas SG, Nieswandt B, Douglas MR, Owen DM, Jackson DG, Dustin ML, Watson SP. Pollitt AY, et al. Among authors: hughes ce. J Biol Chem. 2014 Dec 26;289(52):35695-710. doi: 10.1074/jbc.M114.584284. Epub 2014 Nov 3. J Biol Chem. 2014. PMID: 25368330 Free PMC article.
Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.
Alshehri OM, Montague S, Watson S, Carter P, Sarker N, Manne BK, Miller JL, Herr AB, Pollitt AY, O'Callaghan CA, Kunapuli S, Arman M, Hughes CE, Watson SP. Alshehri OM, et al. Among authors: hughes ce. Biochem J. 2015 Jun 15;468(3):459-73. doi: 10.1042/BJ20150192. Epub 2015 Apr 7. Biochem J. 2015. PMID: 25849538
Minimal regulation of platelet activity by PECAM-1.
Dhanjal TS, Ross EA, Auger JM, McCarty OJ, Hughes CE, Senis YA, Buckley CD, Watson SP. Dhanjal TS, et al. Among authors: hughes ce. Platelets. 2007 Feb;18(1):56-67. doi: 10.1080/09537100600881396. Platelets. 2007. PMID: 17365855 Free PMC article.
CLEC-2 activates Syk through dimerization.
Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP. Hughes CE, et al. Blood. 2010 Apr 8;115(14):2947-55. doi: 10.1182/blood-2009-08-237834. Epub 2010 Feb 12. Blood. 2010. PMID: 20154219 Free PMC article.
362 results