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Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus.
Mike LA, Dutter BF, Stauff DL, Moore JL, Vitko NP, Aranmolate O, Kehl-Fie TE, Sullivan S, Reid PR, DuBois JL, Richardson AR, Caprioli RM, Sulikowski GA, Skaar EP. Mike LA, et al. Among authors: vitko np. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8206-11. doi: 10.1073/pnas.1303674110. Epub 2013 Apr 29. Proc Natl Acad Sci U S A. 2013. PMID: 23630262 Free PMC article.
Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections.
Kumar NS, Dullaghan EM, Finlay BB, Gong H, Reiner NE, Jon Paul Selvam J, Thorson LM, Campbell S, Vitko N, Richardson AR, Zoraghi R, Young RN. Kumar NS, et al. Bioorg Med Chem. 2014 Mar 1;22(5):1708-25. doi: 10.1016/j.bmc.2014.01.020. Epub 2014 Jan 24. Bioorg Med Chem. 2014. PMID: 24508307 Free PMC article.
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