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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.
Daigle SR, Olhava EJ, Therkelsen CA, Majer CR, Sneeringer CJ, Song J, Johnston LD, Scott MP, Smith JJ, Xiao Y, Jin L, Kuntz KW, Chesworth R, Moyer MP, Bernt KM, Tseng JC, Kung AL, Armstrong SA, Copeland RA, Richon VM, Pollock RM. Daigle SR, et al. Among authors: bernt km. Cancer Cell. 2011 Jul 12;20(1):53-65. doi: 10.1016/j.ccr.2011.06.009. Cancer Cell. 2011. PMID: 21741596 Free PMC article.
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.
Bernt KM, Zhu N, Sinha AU, Vempati S, Faber J, Krivtsov AV, Feng Z, Punt N, Daigle A, Bullinger L, Pollock RM, Richon VM, Kung AL, Armstrong SA. Bernt KM, et al. Cancer Cell. 2011 Jul 12;20(1):66-78. doi: 10.1016/j.ccr.2011.06.010. Cancer Cell. 2011. PMID: 21741597 Free PMC article.
A role for DOT1L in MLL-rearranged leukemias.
Bernt KM, Armstrong SA. Bernt KM, et al. Epigenomics. 2011 Dec;3(6):667-70. doi: 10.2217/epi.11.98. Epigenomics. 2011. PMID: 22126283 No abstract available.
Targeting epigenetic programs in MLL-rearranged leukemias.
Bernt KM, Armstrong SA. Bernt KM, et al. Hematology Am Soc Hematol Educ Program. 2011;2011:354-60. doi: 10.1182/asheducation-2011.1.354. Hematology Am Soc Hematol Educ Program. 2011. PMID: 22160057 Review.
Chromatin-modifying enzymes as modulators of reprogramming.
Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Marcarci BO, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ. Onder TT, et al. Among authors: bernt km. Nature. 2012 Mar 4;483(7391):598-602. doi: 10.1038/nature10953. Nature. 2012. PMID: 22388813 Free PMC article.
AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.
Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, Fazio M, Chen CW, Zhu N, Koche R, Dzhekieva L, Ibáñez G, Dias S, Banka D, Krivtsov A, Luo M, Roeder RG, Bradner JE, Bernt KM, Armstrong SA. Deshpande AJ, et al. Among authors: bernt km. Cancer Cell. 2014 Dec 8;26(6):896-908. doi: 10.1016/j.ccell.2014.10.009. Epub 2014 Nov 20. Cancer Cell. 2014. PMID: 25464900 Free PMC article.
64 results