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Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells.
Beck D, Niessner H, Smalley KS, Flaherty K, Paraiso KH, Busch C, Sinnberg T, Vasseur S, Iovanna JL, Drießen S, Stork B, Wesselborg S, Schaller M, Biedermann T, Bauer J, Lasithiotakis K, Weide B, Eberle J, Schittek B, Schadendorf D, Garbe C, Kulms D, Meier F. Beck D, et al. Sci Signal. 2013 Jan 29;6(260):ra7. doi: 10.1126/scisignal.2003057. Sci Signal. 2013. PMID: 23362240 Free PMC article. Clinical Trial.
The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells.
Niessner H, Beck D, Sinnberg T, Lasithiotakis K, Maczey E, Gogel J, Venturelli S, Berger A, Mauthe M, Toulany M, Flaherty K, Schaller M, Schadendorf D, Proikas-Cezanne T, Schittek B, Garbe C, Kulms D, Meier F. Niessner H, et al. Among authors: beck d. J Invest Dermatol. 2011 Feb;131(2):468-79. doi: 10.1038/jid.2010.297. Epub 2010 Oct 14. J Invest Dermatol. 2011. PMID: 20944654 Free article.
Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases.
Niessner H, Forschner A, Klumpp B, Honegger JB, Witte M, Bornemann A, Dummer R, Adam A, Bauer J, Tabatabai G, Flaherty K, Sinnberg T, Beck D, Leiter U, Mauch C, Roesch A, Weide B, Eigentler T, Schadendorf D, Garbe C, Kulms D, Quintanilla-Martinez L, Meier F. Niessner H, et al. Among authors: beck d. Cancer Med. 2013 Feb;2(1):76-85. doi: 10.1002/cam4.50. Epub 2013 Feb 3. Cancer Med. 2013. PMID: 24133630 Free PMC article.
BRAF Inhibitors Amplify the Proapoptotic Activity of MEK Inhibitors by Inducing ER Stress in NRAS-Mutant Melanoma.
Niessner H, Sinnberg T, Kosnopfel C, Smalley KSM, Beck D, Praetorius C, Mai M, Beissert S, Kulms D, Schaller M, Garbe C, Flaherty KT, Westphal D, Wanke I, Meier F. Niessner H, et al. Among authors: beck d. Clin Cancer Res. 2017 Oct 15;23(20):6203-6214. doi: 10.1158/1078-0432.CCR-17-0098. Epub 2017 Jul 19. Clin Cancer Res. 2017. PMID: 28724666 Free PMC article.
Germline UBA1 Variant With Somatic Amplification in a Woman With Inflammatory Diseases and Myelodysplastic Syndrome.
Creignou M, Sirenko M, Moura PL, Mortera-Blanco T, Dimitriou M, Sander B, Domenico D, Arango Ossa JE, Tesi B, Beck DB, Woll P, Jacobsen SW, Papaemmanuil E, Bernard E, Hellström-Lindberg E. Creignou M, et al. Among authors: beck db. Ann Intern Med. 2025 Jan 21. doi: 10.7326/L24-0125. Online ahead of print. Ann Intern Med. 2025. PMID: 39832370 No abstract available.
A decision-space model explains context-specific decision-making.
Beck DW, Heaton CN, Davila LD, Rakocevic LI, Drammis SM, Tyulmankov D, Vara P, Giri A, Umashankar Beck S, Zhang Q, Pokojovy M, Negishi K, Batson SA, Salcido AA, Reyes NF, Macias AY, Ibanez-Alcala RJ, Hossain SB, Waller GL, Moschak TM, Goosens KA, Friedman A. Beck DW, et al. Res Sq [Preprint]. 2024 Dec 3:rs.3.rs-5499511. doi: 10.21203/rs.3.rs-5499511/v1. Res Sq. 2024. PMID: 39678348 Free PMC article. Preprint.
Brain health is essential for smooth economic transitions: towards socio-economic sustainability, productivity and well-being.
Nail-Beatty O, Ibanez A, Ayadi R, Swieboda P, Njamnshi AK, Occhipinti JA, Hynes W, Ikiz B, Castro-Aldrete L, O'Brien K, Platt ML, Adalat S, Abdullah JM, Dhamija RK, Merali Z, Mostert C, Beck D, Saxena S, Salama M, Abdelraheem OM, Destrebecq F, Slavich GM, Shehu B, Fieggen G, Ghogomu PM, Bassetti CLA, Eyre HA. Nail-Beatty O, et al. Among authors: beck d. Brain Commun. 2024 Oct 30;6(6):fcae360. doi: 10.1093/braincomms/fcae360. eCollection 2024. Brain Commun. 2024. PMID: 39670109 Free PMC article.
1,501 results