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Page 1
Down-regulation of CTLA-4 by HIV-1 Nef protein.
El-Far M, Isabelle C, Chomont N, Bourbonnière M, Fonseca S, Ancuta P, Peretz Y, Chouikh Y, Halwani R, Schwartz O, Madrenas J, Freeman GJ, Routy JP, Haddad EK, Sékaly RP. El-Far M, et al. Among authors: freeman gj. PLoS One. 2013;8(1):e54295. doi: 10.1371/journal.pone.0054295. Epub 2013 Jan 23. PLoS One. 2013. PMID: 23372701 Free PMC article.
Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation.
El-Far M, Ancuta P, Routy JP, Zhang Y, Bakeman W, Bordi R, DaFonseca S, Said EA, Gosselin A, Tep TS, Eichbaum Q, van Grevenynghe J, Schwartz O, Freeman GJ, Haddad EK, Chomont N, Sékaly RP. El-Far M, et al. Among authors: freeman gj. J Gen Virol. 2015 Jun;96(Pt 6):1463-1477. doi: 10.1099/vir.0.000065. Epub 2015 Jan 27. J Gen Virol. 2015. PMID: 25626682 Free PMC article.
Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function.
Brunet-Ratnasingham E, Morou A, Dubé M, Niessl J, Baxter AE, Tastet O, Brassard N, Ortega-Delgado G, Charlebois R, Freeman GJ, Tremblay C, Routy JP, Kaufmann DE. Brunet-Ratnasingham E, et al. Among authors: freeman gj. EBioMedicine. 2022 Oct;84:104254. doi: 10.1016/j.ebiom.2022.104254. Epub 2022 Sep 20. EBioMedicine. 2022. PMID: 36150362 Free PMC article.
Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells.
Porichis F, Hart MG, Massa A, Everett HL, Morou A, Richard J, Brassard N, Veillette M, Hassan M, Ly NL, Routy JP, Freeman GJ, Dubé M, Finzi A, Kaufmann DE. Porichis F, et al. Among authors: freeman gj. J Immunol. 2018 Aug 1;201(3):971-981. doi: 10.4049/jimmunol.1701551. Epub 2018 Jun 22. J Immunol. 2018. PMID: 29934472 Free PMC article.
Inadequate T follicular cell help impairs B cell immunity during HIV infection.
Cubas RA, Mudd JC, Savoye AL, Perreau M, van Grevenynghe J, Metcalf T, Connick E, Meditz A, Freeman GJ, Abesada-Terk G Jr, Jacobson JM, Brooks AD, Crotty S, Estes JD, Pantaleo G, Lederman MM, Haddad EK. Cubas RA, et al. Among authors: freeman gj. Nat Med. 2013 Apr;19(4):494-9. doi: 10.1038/nm.3109. Epub 2013 Mar 10. Nat Med. 2013. PMID: 23475201 Free PMC article.
Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.
Kaufmann DE, Kavanagh DG, Pereyra F, Zaunders JJ, Mackey EW, Miura T, Palmer S, Brockman M, Rathod A, Piechocka-Trocha A, Baker B, Zhu B, Le Gall S, Waring MT, Ahern R, Moss K, Kelleher AD, Coffin JM, Freeman GJ, Rosenberg ES, Walker BD. Kaufmann DE, et al. Among authors: freeman gj. Nat Immunol. 2007 Nov;8(11):1246-54. doi: 10.1038/ni1515. Epub 2007 Sep 30. Nat Immunol. 2007. PMID: 17906628
446 results