Finel M - Search Results

1

Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent.

Manevski N, Troberg J, Svaluto-Moreolo P, Dziedzic K, Yli-Kauhaluoma J, Finel M. Manevski N, et al. Among authors: finel m. PLoS One. 2013;8(1):e54767. doi: 10.1371/journal.pone.0054767. Epub 2013 Jan 23. PLoS One. 2013. PMID: 23372764 Free PMC article.

2

Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.

Manevski N, Kurkela M, Höglund C, Mauriala T, Court MH, Yli-Kauhaluoma J, Finel M. Manevski N, et al. Among authors: finel m. Drug Metab Dispos. 2010 Mar;38(3):386-95. doi: 10.1124/dmd.109.031138. Epub 2009 Dec 10. Drug Metab Dispos. 2010. PMID: 20007669 Free PMC article.

3

Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9.

Manevski N, Moreolo PS, Yli-Kauhaluoma J, Finel M. Manevski N, et al. Among authors: finel m. Drug Metab Dispos. 2011 Nov;39(11):2117-29. doi: 10.1124/dmd.111.041418. Epub 2011 Aug 19. Drug Metab Dispos. 2011. PMID: 21856742

4

UDP-glucuronic acid binds first and the aglycone substrate binds second to form a ternary complex in UGT1A9-catalyzed reactions, in both the presence and absence of bovine serum albumin.

Manevski N, Yli-Kauhaluoma J, Finel M. Manevski N, et al. Among authors: finel m. Drug Metab Dispos. 2012 Nov;40(11):2192-203. doi: 10.1124/dmd.112.047746. Epub 2012 Aug 21. Drug Metab Dispos. 2012. PMID: 22912433

5

Stereochemical sensitivity of the human UDP-glucuronosyltransferases 2B7 and 2B17.

Bichlmaier I, Siiskonen A, Finel M, Yli-Kauhaluoma J. Bichlmaier I, et al. Among authors: finel m. J Med Chem. 2006 Mar 9;49(5):1818-27. doi: 10.1021/jm051142c. J Med Chem. 2006. PMID: 16509597

6

Chiral distinction between the enantiomers of bicyclic alcohols by UDP-glucuronosyltransferases 2B7 and 2B17.

Bichlmaier I, Siiskonen A, Kurkela M, Finel M, Yli-Kauhaluoma J. Bichlmaier I, et al. Among authors: finel m. Biol Chem. 2006 Apr;387(4):407-16. doi: 10.1515/BC.2006.055. Biol Chem. 2006. PMID: 16606339

7

Eudismic analysis of tricyclic sesquiterpenoid alcohols: lead structures for the design of potent inhibitors of the human UDP-glucuronosyltransferase 2B7.

Bichlmaier I, Kurkela M, Siiskonen A, Finel M, Yli-Kauhaluoma J. Bichlmaier I, et al. Among authors: finel m. Bioorg Chem. 2007 Oct;35(5):386-400. doi: 10.1016/j.bioorg.2007.07.002. Epub 2007 Aug 15. Bioorg Chem. 2007. PMID: 17706742

8

Stereochemical and steric control of the UDP-glucuronosyltransferase-catalyzed conjugation reaction: a rational approach for the design of inhibitors for the human UGT2B7.

Bichlmaier I, Finel M, Sippl W, Yli-Kauhaluoma J. Bichlmaier I, et al. Among authors: finel m. ChemMedChem. 2007 Dec;2(12):1730-40. doi: 10.1002/cmdc.200700122. ChemMedChem. 2007. PMID: 17943712

9

UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly.

Sten T, Bichlmaier I, Kuuranne T, Leinonen A, Yli-Kauhaluoma J, Finel M. Sten T, et al. Among authors: finel m. Drug Metab Dispos. 2009 Feb;37(2):417-23. doi: 10.1124/dmd.108.024844. Epub 2008 Nov 20. Drug Metab Dispos. 2009. PMID: 19022937

10

Synthesis, structure characterization, and enzyme screening of clenbuterol glucuronides.

Alonen A, Gartman M, Aitio O, Finel M, Yli-Kauhaluoma J, Kostiainen R. Alonen A, et al. Among authors: finel m. Eur J Pharm Sci. 2009 Jul 12;37(5):581-7. doi: 10.1016/j.ejps.2009.05.003. Epub 2009 May 15. Eur J Pharm Sci. 2009. PMID: 19447177

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