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FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer.
Hollier BG, Tinnirello AA, Werden SJ, Evans KW, Taube JH, Sarkar TR, Sphyris N, Shariati M, Kumar SV, Battula VL, Herschkowitz JI, Guerra R, Chang JT, Miura N, Rosen JM, Mani SA. Hollier BG, et al. Among authors: sphyris n. Cancer Res. 2013 Mar 15;73(6):1981-92. doi: 10.1158/0008-5472.CAN-12-2962. Epub 2013 Feb 1. Cancer Res. 2013. PMID: 23378344 Free PMC article.
pIgR: frenemy of inflammation, EMT, and HCC progression.
Sphyris N, Mani SA. Sphyris N, et al. J Natl Cancer Inst. 2011 Nov 16;103(22):1644-5. doi: 10.1093/jnci/djr421. Epub 2011 Oct 24. J Natl Cancer Inst. 2011. PMID: 22025623 Free PMC article. No abstract available.
EMT-induced metabolite signature identifies poor clinical outcome.
Bhowmik SK, Ramirez-Peña E, Arnold JM, Putluri V, Sphyris N, Michailidis G, Putluri N, Ambs S, Sreekumar A, Mani SA. Bhowmik SK, et al. Among authors: sphyris n. Oncotarget. 2015 Dec 15;6(40):42651-60. doi: 10.18632/oncotarget.4765. Oncotarget. 2015. PMID: 26315396 Free PMC article.
Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties.
Paranjape AN, Soundararajan R, Werden SJ, Joseph R, Taube JH, Liu H, Rodriguez-Canales J, Sphyris N, Wistuba I, Miura N, Dhillon J, Mahajan N, Mahajan K, Chang JT, Ittmann M, Maity SN, Logothetis C, Tang DG, Mani SA. Paranjape AN, et al. Among authors: sphyris n. Oncogene. 2016 Nov 17;35(46):5963-5976. doi: 10.1038/onc.2015.498. Epub 2016 Jan 25. Oncogene. 2016. PMID: 26804168 Free PMC article.
Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth.
Werden SJ, Sphyris N, Sarkar TR, Paranjape AN, LaBaff AM, Taube JH, Hollier BG, Ramirez-Peña EQ, Soundararajan R, den Hollander P, Powell E, Echeverria GV, Miura N, Chang JT, Piwnica-Worms H, Rosen JM, Mani SA. Werden SJ, et al. Among authors: sphyris n. Oncogene. 2016 Nov 17;35(46):5977-5988. doi: 10.1038/onc.2016.203. Epub 2016 Jun 13. Oncogene. 2016. PMID: 27292262 Free PMC article.
26 results